Misoprostol versus combined regimen of mifepristone and misoprostol in termination of second trimester pregnancy
DOI:
https://doi.org/10.18203/2320-1770.ijrcog20251421Keywords:
Second trimester termination of pregnancy, Mifepristone, Misoprostol, Surgical intervention D and E, Induction abortion intervalAbstract
The present prospective study was conducted over 12 months at Dr. Mansukh Bhai K. Shah medical college and Sushilaben M. Shah multi-specialty hospital, Ahmedabad, serving predominantly lower socioeconomic groups. The objective was to assess the safety and efficacy of misoprostol alone versus a combined regimen of mifepristone and misoprostol in second-trimester pregnancy termination. A total of 18 patients were enrolled and divided into two groups. Group A received 200 mg oral mifepristone, followed 24 hours later by 200 mcg misoprostol administered vaginally every 4 hours up to a maximum of 4 doses or until expulsion occurred. Group B received only 200 mcg vaginal misoprostol every 4 hours, up to 4 doses. Success was defined as complete expulsion of the fetus and placenta without the need for surgical intervention. In group A, the success rate was 100%, and none of the patient’s required dilatation and evacuation (D and E). In contrast, group B had a success rate of 80%, with 2 patients (20%) requiring D and E. There were no failures in either group, defined as failure to abort within 72 hours of the last dose. The induction-abortion interval was shorter in the mifepristone-primed group. The study concludes that pre-treatment with mifepristone significantly improves the efficacy of second-trimester pregnancy termination with misoprostol, reduces the need for Surgical intervention, and shortens the induction-to-abortion interval. The combined regimen of mifepristone and misoprostol is thus more effective and safer than misoprostol alone.
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References
Morris A, Meaney S, Spillane N, O'Donoghue K. The postnatal morbidity associated with second trimester miscarriage. J matern fetal neonatal Med. 2016;29(17):2786. DOI: https://doi.org/10.3109/14767058.2015.1103728
Nagaria T, Sirmor N. Misoprostol vs mifepristone and Misoprostol in second trimester Termination of pregnancy. J Obstet Gynaecol India. 2011;61(6):659-62. DOI: https://doi.org/10.1007/s13224-011-0118-4
Kapp N, Borgatta L, Stubblefield PG, Olivera V, Nilda M. Mifepristone in mid trimester medical abortion: a randomized controlled trial. Obstet Gynecol. 2007;110(6):1304. DOI: https://doi.org/10.1097/01.AOG.0000289577.32274.a5
Ngoc NT, Shochet T, Raghavan S, Blum J, Nga NT, Minh NTHM, et al. Mifepristone and misoprostol compared with misoprostol alone for second trimester abortion. Obstet Gynecol. 2011;118(3):601. DOI: https://doi.org/10.1097/AOG.0b013e318227214e
Wong KS, Ngai CS, Yeo EL, Tang LC, Ho PC. A comparison of two regimens of intravaginal misoprostol for termination of second trimester pregnancy: a randomized comparative trial. Hum Reprod. 2000;15(3):709-12. DOI: https://doi.org/10.1093/humrep/15.3.709
Herbutya Y, Chanarchakul B, Punyavachira P. Vaginal misoprostol in the termination of second trimester pregnancy. J Obstet Gynaecol Res. 2000;26(2):121-5. DOI: https://doi.org/10.1111/j.1447-0756.2000.tb01294.x
Pongsatha S, Tongsong T. Second trimester pregnancy termination with 800 mcg vaginal misoprostol. Med Assoc Thai. 2001;84(6):859-63.
Herbutya Y, Chanarchakul B, Punyavachira P. Second trimester pregnancy termination: a comparison of 600 and 800l g of intravaginal misoprostol. J Obstet Gynaecol Res. 2001;27(3):125-8. DOI: https://doi.org/10.1111/j.1447-0756.2001.tb01235.x
Gilbert A, Reid R. A randomized trial of oral versus vaginal administration of misoprostol for the purpose of mid trimester termination of pregnancy. Aust N ZJ Obstet Gynaecol. 2001;41(4):407-10. DOI: https://doi.org/10.1111/j.1479-828X.2001.tb01318.x
Ramin KD, Ogburn PL, Danilenko DR, Ramsey PS. High dose oral misoprostol for mid trimester pregnancy interruption. J Gynecol Obstet Invest. 2002;54(3):176-9. DOI: https://doi.org/10.1159/000067889
Dickinson JE, Evans SF. A comparison of oral misoprostol with vaginal misoprostol administration in second- trimester pregnancy termination for fetal abnormality. Obstet Gynecol. 2003;102(6):1294-9. DOI: https://doi.org/10.1097/00006250-200306000-00026
Tang OS, Lau WNT, Chan CCW, Ho PC. Aprospective randomized comparison of sublingual and vaginal misoprostol in second trimester termination of pregnancy. Br J Obstet Gyneacol. 2004;11(9):1001-5. DOI: https://doi.org/10.1111/j.1471-0528.2004.00222.x
Pongastha S, Tongsong T. Therapeutic termination of second trimester pregnancies with intrauterine fetal death with 400l g of oral misoprostol. J Obstet Gynaecol Res. 2004;30(3):217-20. DOI: https://doi.org/10.1111/j.1447-0756.2004.00184.x
Baird DT, Rodger MW. Pretreatment with mifepristone (RU486) reduces interval between prostaglandin administration and expulsion in second trimester abortion. Br J Obstet Gyneacol. 1990;97(1):41-5. DOI: https://doi.org/10.1111/j.1471-0528.1990.tb01714.x
Hinshaw K, Refaey HE. Mid trimester termination for fetal abnormality: advantages of a new regimen suing mifepristone and misoprostol. Br J Obstet Gyneacol. 1995;102(7):559-60. DOI: https://doi.org/10.1111/j.1471-0528.1995.tb11361.x
Refaey HE, Templeton A. Induction of abortion in the second trimester by a combination of misoprostol and mifepristone: a randomized comparison between two misoprostol regimens. Hum Reprod. 1995;10(2):475-8. DOI: https://doi.org/10.1093/oxfordjournals.humrep.a135965
HOPC, Tsang SSK, MaHK. Reducing the induction to abortion interval in termination of second trimester pregnancies: a comparison of mifepristone with luminaria tent. Br J Obstet Gyneacol. 1995;102(8):648-51. DOI: https://doi.org/10.1111/j.1471-0528.1995.tb11404.x
Premila WA, Templeton A. Nonsurgical mid trimester termination of pregnancy; a review of 500 consecutive cases. Br J Obstet Gyneacol. 1999;106(7):706-10. DOI: https://doi.org/10.1111/j.1471-0528.1999.tb08371.x
Ngai SW, Tang OS, Pak Chiung HO. Randomized comparison of vaginal (200 lg every 3 h) and oral (400 lg every 3h) misoprostol when combined with mifepristone in termination of second trimester pregnancy. Hum Reprod. 2001;15(10):2205-8. DOI: https://doi.org/10.1093/humrep/15.10.2205