Association of maternal serum ferritin level with preterm labor

Authors

  • Popy R. Kundu Department of Obstetrics and Gynaecology, Specialized Hospital, Khulna, Bangladesh
  • M. Nupur Aktar Department of Obstetrics and Gynaecology, Upazila Health Complex, Daganbhuiyan, Feni, Bangladesh
  • Umme S. Shilpi Department of Obstetrics and Gynaecology, Kurmitola General Hospital, Dhaka, Bangladesh
  • Tanzin Hossain Department of Obstetrics and Gynaecology, Kurmitola General Hospital, Dhaka, Bangladesh
  • Rubab Sarmin Department of Obstetrics and Gynaecology, Upazila Health Complex, Chowgacha, Jashore, Bangladesh
  • Sarna Tarafder Department of Obstetrics and Gynaecology, Dhaka Medical College, Dhaka, Bangladesh
  • Jannatul F. Chowdhury Department of Obstetrics and Gynaecology, Sarkari Karmachari Hospital, Dhaka, Bangladesh
  • Khadiza A. Sumi Department of Obstetrics and Gynaecology, 250 Bed General Hospital, Chandpur Sadar, Chandpur, Bangladesh

DOI:

https://doi.org/10.18203/2320-1770.ijrcog20251558

Keywords:

Preterm labor, Serum ferritin, Biomarker, Pregnancy, Maternal health

Abstract

Background: Preterm labor is a significant contributor to neonatal morbidity and mortality worldwide. Identifying reliable biomarkers for predicting preterm birth can improve maternal and neonatal outcomes. Serum ferritin, an acute-phase reactant and iron storage protein, may play a role in the pathophysiology of preterm labor. This study aimed to evaluate the association between maternal serum ferritin levels and preterm labor.

Methods: A case-control study was conducted in the Department of Obstetrics and Gynaecology at Dhaka Medical College Hospital from June 2022 to May 2023. A total of 88 pregnant women were enrolled using purposive sampling, including 44 with preterm labor (cases) and 44 with term labor (controls). Sociodemographic, obstetric, and biochemical data were collected, and maternal serum ferritin levels were measured. Data were analyzed using statistical package for the social sciences (SPSS) version 25, and comparisons between groups were made using the Mann-Whitney U test and Chi-square test where appropriate.

Results: There was no significant difference in maternal age between the two groups. However, serum ferritin levels were significantly higher in the preterm group (89.09±106.07 ng/ml) compared to the term group (32.13±31.40 ng/ml) (p=0.004). A weak but statistically significant negative correlation was observed between serum ferritin levels and gestational age (r=-0.313, p<0.05).

Conclusions: Elevated maternal serum ferritin levels are significantly associated with preterm labor. Serum ferritin may serve as a useful biomarker for identifying women at risk of preterm delivery, allowing for timely interventions to prevent adverse pregnancy outcomes.

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References

Singh B, Goswami B, Gupta N, Bajaj AD, Mallika V. Potential biochemical markers for preterm labor: a pilot study in north India. Indian J Clin Biochem. 2011;26(1):41-5. DOI: https://doi.org/10.1007/s12291-010-0081-3

Lee AC, Blencowe H, Lawn JE. Small babies, big numbers: global estimates of preterm birth. Lancet Glob Health. 2019;7(1):e2-e3. DOI: https://doi.org/10.1016/S2214-109X(18)30484-4

Movahedi M, Saiedi M, Gharipour M, Aghadavoudi O. Diagnostic performance and discriminative value of the serum ferritin level for predicting preterm labor. J Res Med Sci. 2012;17(2):164-6.

Koucký M, Germanová A, Hájek Z, Parízek A, Kalousová M, Kopecký P. News in pathophysiology and management of preterm labour. Ceska Gynekol. 2009;74(1):54-63.

Ananth CV, Getahun D, Peltier MR, Salihu HM, Vintzileos AM. Recurrence of spontaneous versus medically indicated preterm birth. Am J Obstet Gynecol. 2006;195(3):643-50. DOI: https://doi.org/10.1016/j.ajog.2006.05.022

Swingle HM, Colaizy TT, Zimmerman MB, Morriss FH Jr. Abortion and the risk of subsequent preterm birth: a systematic review with meta-analyses. J Reprod Med. 2009;54(2):95-108.

Kurdi AM, Mesleh RA, Al-Hakeem MM, Khashoggi TY, Khalifa HM. Multiple pregnancy and preterm labor. Saudi Med J. 2004;25(5):632-7.

Hossain R, Harris T, Lohsoonthorn V, Williams MA. Risk of preterm delivery in relation to vaginal bleeding in early pregnancy. Eur J Obstet Gynecol Reprod Biol. 2007;135(2):158-63. DOI: https://doi.org/10.1016/j.ejogrb.2006.12.003

Zhang Q, Ananth CV, Li Z, Smulian JC. Maternal anaemia and preterm birth: a prospective cohort study. Int J Epidemiol. 2009;38(5):1380-9. DOI: https://doi.org/10.1093/ije/dyp243

Chan YY, Jayaprakasan K, Zamora J, Thornton JG, Raine-Fenning N, Coomarasamy A. The prevalence of congenital uterine anomalies in unselected and high-risk populations: a systematic review. Hum Reprod Update. 2011;17(6):761-71. DOI: https://doi.org/10.1093/humupd/dmr028

Dunietz GL, Holzman C, McKane P, Li C, Boulet SL, Todem D, et al. Assisted reproductive technology and the risk of preterm birth among primiparas. Fertil Steril. 2015;103(4):974-9. DOI: https://doi.org/10.1016/j.fertnstert.2015.01.015

Smith GC, Shah I, Crossley JA, Aitken DA, Pell JP, Nelson SM, et al. Pregnancy-associated plasma protein A and alpha-fetoprotein and prediction of adverse perinatal outcome. Obstet Gynecol. 2006;107(1):161-6. DOI: https://doi.org/10.1097/01.AOG.0000191302.79560.d8

Cnattingius S, Villamor E, Johansson S, Edstedt Bonamy AK, Persson M, Wikström AK, et al. Maternal obesity and risk of preterm delivery. JAMA. 2013;309(22):2362-70. DOI: https://doi.org/10.1001/jama.2013.6295

Heaman M, Kingston D, Chalmers B, Sauve R, Lee L, Young D. Risk factors for preterm birth and small-for-gestational-age births among Canadian women. Paediatr Perinat Epidemiol. 2013;27(1):54-61. DOI: https://doi.org/10.1111/ppe.12016

Mohamed HI, Sadek AM, Mahmoud BS, Sakr BE. Maternal Serum Ferritin Concentrations as a Predictor of Preterm Labour. Benha J Appl Sci. 2021;6(4):177-82. DOI: https://doi.org/10.21608/bjas.2021.189914

Siddika A, Nasrin B, Shamim S, Begum N, Nahar N, Begum SR. Serum Ferritin Level in Preterm Labour. Bangl J Obstet Gynaecol. 2009;24(1):14-7. DOI: https://doi.org/10.3329/bjog.v24i1.6321

Jahedbozorgan T, Yaghmaei M, Naserieh M. Comparison of serum ferritin levels in pregnant women with preterm and term deliveries. Immunopathologia Persa. 2020;6(2):e25. DOI: https://doi.org/10.34172/ipp.2020.25

Abdel-Malek K, El-Halwagi MA, Hammad BE, Azmy O, Helal O, Eid M, et al. Role of maternal serum ferritin in prediction of preterm labour. J Obstet Gynaecol. 2018;38(2):222-5. DOI: https://doi.org/10.1080/01443615.2017.1347915

Weintraub AY, Sheiner E, Mazor M, Levy A, Tevet A, Paamoni O, et al. Maternal serum ferritin concentration in patients with preterm labor and intact membranes. J Matern Fetal Neonatal Med. 2005;18(3):163-6. DOI: https://doi.org/10.1080/14767050500244610

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Published

2025-05-29

How to Cite

Kundu, P. R., Aktar, M. N., Shilpi, U. S., Hossain, T., Sarmin, R., Tarafder, S., Chowdhury, J. F., & Sumi, K. A. (2025). Association of maternal serum ferritin level with preterm labor. International Journal of Reproduction, Contraception, Obstetrics and Gynecology, 14(6), 1739–1743. https://doi.org/10.18203/2320-1770.ijrcog20251558

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Original Research Articles