Bacteriological assessment on urinary tract infection in preterm premature rupture of the membranes and preterm labour related to fetomaternal outcomes

Ganesh M. Bargaje; Roshan Hussain

doi:10.18203/2320-1770.ijrcog20251978

Authors

Ganesh M. Bargaje Department of Obstetrics and Gynaecology, New Thergaon Hospital, Thergaon, Pimpri-Chinchwad, Pune, Maharashtra, India
Roshan Hussain Department of Obstetrics and Gynaecology, Jawaharlal Nehru Hospital and Research Centre, Bhilai, Chhattisgarh, India

DOI:

https://doi.org/10.18203/2320-1770.ijrcog20251978

Keywords:

Antibiotic sensitivity, Bacterial infection, Fetomaternal outcome, Urinary tract infection, PPROM

Abstract

Background: Urinary tract infection (UTI) is a health hazards risk during pregnancy of mothers, which leads to preterm premature rupture of the membranes (PPROM) following preterm labour (PTL). The objective was to investigate the most common bacteria causing UTI in cases presenting with PPROM following PTL and also their sensitivity profile to antibiotics and fetomaternal outcome in such cases at tertiary care hospital, Central India.

Methods: This research was conducted a hospital-based prospective and observational study among 60 pregnant women for the period of 01 July 2020 to 30 June 2021 in the tertiary care hospital at Bhilai, Chhattisgarh. Also studied urine for culture and sensitivity test for antibiotics related to fetomaternal outcomes.

Results: Among the marker of infection of total studied patients, a maximum for UCS positive (21.7%) and WBC count >15000 cumm (15.0%) while minimum for CRP (10.0%). Among the various microorganisms isolated in urine culture of participants, a higher value was observed on E. coli (11.67%) followed by Klebsiella sp. and Proteus sp. (3.33%) while lower value was observed for Pseudomonas sp. and CoNS (1.67%) among total studied patients. The association between urine culture and maternal complications, type of delivery, did not show significant association. No significant association was observed between urine culture and different parameters of neonatal complications and neonatal death. Only two deaths of babies were recorded.

Conclusions: UTI is significant causative factors of PTL and PPROM. It is always suggested to screen and monitor the antenatal mothers for the presence of asymptomatic or symptomatic UTI.

Metrics

Metrics Loading ...

References

Talungchit P, Ruangvutilert P, Boonbowornpong TP, Phattanachindakun B. Prevalence of urinary tract infection in pregnancies with premature uterine contractions. Siriraj Med J. 2023;75(10):699-706. DOI: https://doi.org/10.33192/smj.v75i10.264256

Kerure RD, Biradar AV, Lakshetty S, Biradar S. A study of urinary tract infection in pregnancy and its effect on maternal and perinatal outcome. Int J Reprod Contracept Obstet Gynecol. 2024;13(2):284-9. DOI: https://doi.org/10.18203/2320-1770.ijrcog20240031

Schmiemann G, Kniehl E, Gebhardt K, Matejczyk MM, Hummers-Pradier E. The diagnosis of urinary tract infection: a systematic review. Dtsch Arztebl Int. 2010;107(21):361-7. DOI: https://doi.org/10.3238/arztebl.2010.0361

Esha M. Urinary tract infection and its effects on outcome of pregnancy. Indian J of Obstet and Gynec Res. 2017;4(2):108-11.

Flores-Mireles AL, Walker JN, Caparon M, Hultgren SJ. Urinary tract infections: Epidemiology, mechanisms of infection and treatment options. Nat Rev Microbiol. 2015;13(5):269-84. DOI: https://doi.org/10.1038/nrmicro3432

Habak PJ, Griggs, Jr RP. Urinary tract infection in pregnancy. In: StatPearls. Treasure Island (FL): StatPearls Publishing. 2021.

Dheepthambiga G, Sethuraman D, Revwathy S. Study of association of urinary tract infection with preterm labour. Indian J Obstet Gynecol Res. 2020;7(4):567-72.

Bargaje GM, Hussain R. Study of prevalence of genital tract infection in preterm premature rupture of the membranes and preterm labour following fetomaternal outcomes. Int J Reprod Contracept Obstet Gynecol. 2024;13(12):3642-7. DOI: https://doi.org/10.18203/2320-1770.ijrcog20243598

Kass EH. Asymptomatic infections of the urinary tract. Trans Assoc Am Physicians. 1956;69:56-64.

Vogel JP, Lee AC, Souza JP. Maternal morbidity and preterm birth in 22 low- and middle-income countries: A secondary analysis of the WHO Global Survey dataset. BMC Pregnancy Childbirth. 2014;14:56. DOI: https://doi.org/10.1186/1471-2393-14-56

Vrishali G, Anjali P, Kshirsagar N. Urogenital infections – A cause of pre term labor. Int J Contemp Med Res. 2017;4(4):888-91.

Yarlagadda S, Sajana G, Narra PJ. Association of vaginal infections in preterm labour. Int J Reprod Contracept Obstet Gynecol. 2018;7(6):2174-9. DOI: https://doi.org/10.18203/2320-1770.ijrcog20182030

Dheepthambiga G, Sethuraman D, Revwathy S. Study of association of urinary tract infection with preterm labour. Indian J Obstet Gynecol Res. 2020;7(4):567-72. DOI: https://doi.org/10.18231/j.ijogr.2020.121

Singh S, Swain S, Das L, Das PC, Sahoo S. Isolation and characterization of organisms in high vaginal swab culture in preterm pregnancy (28-37 week). Int J Reprod Contracept Obstet Gynecol. 2016;5(11):3853-8. DOI: https://doi.org/10.18203/2320-1770.ijrcog20163853

Satija A, Satija V, Kaur J, Bains HS. Prospective analysis of preterm labour: Its etiology and outcome. Int J Basic Appl Med Sci. 2014;4(2):70-7.

Amulya C, Varada A, Radha T. Bacteriological study of genitourinary cultures in preterm labour cases in teaching hospitals – 1 year study. Int Arch Integrat Med. 2015;2(12):11-5.

Mahor S, Malviya R, Goyal R. Study of incidence of urinary tract infection during pregnancy and its effect on maternal and perinatal outcome. Int J Reprod Contracept Obstet Gynecol. 2021;10:1497-502. DOI: https://doi.org/10.18203/2320-1770.ijrcog20211127

Satija A, Satija V, Kaur J, Bains HS. Prospective analysis of preterm labour: Its etiology and outcome. Int J Basic Appl Med Sci. 2014;4(2):70-7.