Clinical management and successful pregnancy outcomes in women with empty Sella syndrome undergoing assisted reproductive technology: a case-based approach
DOI:
https://doi.org/10.18203/2320-1770.ijrcog20252001Keywords:
Empty Sella syndrome, Infertility, Ovarian stimulation, Assisted reproductive technologyAbstract
Empty Sella syndrome (ESS) is a radiological condition characterized by a partially or completely flattened pituitary gland within the sella turcica, which may impact reproductive function. This case report presents two women with ESS undergoing in vitro fertilization (IVF). Despite having ESS, patient A had a normal ovarian reserve and conceived after frozen embryo transfer (FET) and regulated ovarian stimulation. Patient B needed an oocyte donation program in order to achieve pregnancy because of their significantly reduced ovarian reserve (AMH=0.01 ng/ml). The fact that both patients were able to conceive shows how important it is to use customized assisted reproductive technology (ART) plans depending on ovarian function. ESS presents a heterogeneous impact on fertility, necessitating tailored treatment plans, including optimized ovarian stimulation, embryo transfer protocols, and donor oocyte utilization. A multidisciplinary approach involving reproductive endocrinologists and fertility specialists is crucial in managing ESS-related infertility to maximize pregnancy success.
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Vemparala P, Challagulla S. 8168 From Salt to the Sella-Discovering Empty Sella Syndrome as a Rare Cause of Severe Hyponatremia. J Endocrine Society. 2024;8(1):bvae163-1216. DOI: https://doi.org/10.1210/jendso/bvae163.1216
Ekhzaimy AA, Mujammami M, Tharkar S, Alansary MA, Al Otaibi D. Clinical presentation, evaluation and case management of primary empty Sella syndrome: a retrospective analysis of 10-year single-center patient data. BMC Endocrine Disorders. 2020;20(1):142. DOI: https://doi.org/10.1186/s12902-020-00621-5
Herman T, Török P, Laganà AS, Jakab A. In vitro fertilization treatment of a patient with primary partial empty Sella and other co-factors. Obstet Gynecol Cases Rev. 2020;7:174. DOI: https://doi.org/10.23937/2377-9004/1410174
Poggi M, Monti S, Lauri C, Pascucci C, Bisogni V, Toscano V. Primary empty sella and GH deficiency: prevalence and clinical implications. Ann Dell'Istituto Superiore Sanita. 2012;48:91-6.
Buchfelder M, Brockmeier S, Pichl J, Schrell U, Fahlbusch R. Results of dynamic endocrine testing of hypothalamic pituitary function in patients with a primary “empty” sella syndrome. Hormone Metabol Res. 1989;21(10):573-6. DOI: https://doi.org/10.1055/s-2007-1009290
Ahamed A, Shetty S, Hegde S, Prasannan P. The emptiness within: a case of empty Sella syndrome. Cureus. 2022;14(9):e28941. DOI: https://doi.org/10.7759/cureus.28941
Ghaffari F, Arabipoor A, Lankarani NB, Etminan Z, Tehraninejad ES. Assisted reproductive technique outcomes in hypogonadotropic hypogonadism women. Ann Saudi Med. 2013;33(3):235-40. DOI: https://doi.org/10.5144/0256-4947.2013.235
Wu Y, Gao X, Lu X, Xi J, Jiang S, Sun Y, et al. Endometrial thickness affects the outcome of in vitro fertilization and embryo transfer in normal responders after GnRH antagonist administration. Reproduct Biol Endocrinol. 2014;12:1-5. DOI: https://doi.org/10.1186/1477-7827-12-96
Della Corte C, Della Corte R, Festa M. Empty Sella syndrome in obese patient with cushingoid features. Description of a clinical case. Minerva Medica. 1993;84(6):347-50.
Musa E, Alonge B, Shok D, Stephen W. Primary Empty Sella Syndrome in a Woman with Metabolic Syndrome Presenting with Syncopal Attack: A Case Report. Nig J Med. 2019;28(4):536-9. DOI: https://doi.org/10.4103/1115-2613.278645
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