Overcoming poor ovarian reserve: a case report series of spontaneous conception after failed intracytoplasmic sperm injection
DOI:
https://doi.org/10.18203/2320-1770.ijrcog20251990Keywords:
Poor ovarian reserve, Infertility, Ovarian stimulation, Assisted reproductive treatment, Spontaneous conceptionAbstract
This case report addresses the possibility of spontaneous conception in women with diminished poor ovarian reserve (POR) after multiple failure of assisted reproductive technology (ART) cycles, including intrauterine insemination (IUI) and intracytoplasmic sperm injection (ICSI). Four cases were analyzed, including patients aged 31 to 41 years, each with a unique clinical profile for POR. These patients were infertile for durations of 5 to 12 years, as well as with other conditions like hypothyroidism and raised BMI. Recombinant FSH was used in all cases for ovarian stimulation, but the outcome was suboptimal with poor oocyte retrieval rates and fertilization failure. The cumulative follicle-stimulating hormone (FSH) dose used in patients ranged from 1875 IU to 3000 IU. This strategy produced a low yield of oocytes, most of which were immature or failed to fertilize. Remarkably, all four patients subsequently conceived spontaneously and gave birth to healthy babies without additional ART treatments, despite the difficulty encountered in the ART cycles. The observation that spontaneous conception was successful in these complicated cases underscores the need for further studies into the mechanisms underlying such events to occur, especially in patients who have had multiple failure with ART. This case report underscores the merit of individualized treatment strategies and continued investigation into the determinants influencing fertility in women with POR.
Metrics
References
Nelson SM, Telfer EE, Anderson RA. The ageing ovary and uterus: new biological insights. Human Reproduct Update. 2013;19(1):67-83. DOI: https://doi.org/10.1093/humupd/dms043
Polyzos NP, Devroey P. A systematic review of randomized trials for the treatment of poor ovarian responders: is there any light at the end of the tunnel? Fertil Steril. 2011;96(5):1058-61. DOI: https://doi.org/10.1016/j.fertnstert.2011.09.048
Ferraretti A, La Marca A, Fauser BC, Tarlatzis B, Nargund G, Gianaroli L, et al. ESHRE consensus on the definition of ‘poor response'to ovarian stimulation for in vitro fertilization: the Bologna criteria. Human Reproduct. 2011;26(7):1616-24. DOI: https://doi.org/10.1093/humrep/der092
Banker M, Sorathiya D, Shah S. Effect of body mass index on the outcome of in-vitro fertilization/intracytoplasmic sperm injection in women. J Human Reproduct Sci. 2017;10(1):37-43.
Younis JS. Ovarian aging: latest thoughts on assessment and management. Curr Opin Obstetr Gynecol. 2011;23(6):427-34. DOI: https://doi.org/10.1097/GCO.0b013e32834b92b0
Toner JP, Coddington CC, Doody K, Van Voorhis B, Seifer DB, Ball GD, et al. Society for Assisted Reproductive Technology and assisted reproductive technology in the United States: a 2016 update. Fertil Steril. 2016;106(3):541-6. DOI: https://doi.org/10.1016/j.fertnstert.2016.05.026
Legro RS, Arslanian SA, Ehrmann DA, Hoeger KM, Murad MH, Pasquali R, et al. Diagnosis and treatment of polycystic ovary syndrome: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metabol. 2013;98(12):4565-92. DOI: https://doi.org/10.1210/jc.2013-2350
Heijnen EM, Eijkemans MJ, De Klerk C, Polinder S, Beckers NG, Klinkert ER, et al. A mild treatment strategy for in-vitro fertilisation: a randomised non-inferiority trial. The Lancet. 2007;369(9563):743-9. DOI: https://doi.org/10.1016/S0140-6736(07)60360-2