Effect of Elagolix in comparison to Dienogest in the treatment of symptomatic adenomyosis

Authors

  • Umme Jubaida Department of Reproductive Endocrinology and Infertility (OSD), Directorate General of Health Services (DGHS), Dhaka, Bangladesh
  • Farzana Deeba Department of Reproductive Endocrinology and Infertility, Bangladesh Medical University, Dhaka, Bangladesh
  • Shakeela Ishrat Department of Reproductive Endocrinology and Infertility, Bangladesh Medical University, Dhaka, Bangladesh
  • Shaheen Ara Anwary Department of Reproductive Endocrinology and Infertility, Bangladesh Medical University, Dhaka, Bangladesh
  • Rebeka Sultana Department of Reproductive Endocrinology and Infertility (OSD), Directorate General of Health Services (DGHS), Dhaka, Bangladesh
  • Chowdhury Faisal Alamgir Department of Urology, New Cross Hospital, The Royal Wolverhampton NHS Trust, United Kingdom
  • Maliha Darmini Department of Gynecology, Mymensingh Medical College and Hospital, Mymensingh, Bangladesh
  • Jesmine Banu Department of Reproductive Endocrinology and Infertility, Bangladesh Medical University, Dhaka, Bangladesh

DOI:

https://doi.org/10.18203/2320-1770.ijrcog20251977

Keywords:

Symptomatic adenomyosis, Dysmenorrhoea, Heavy menstrual bleeding, Elagolix, Dienogest

Abstract

Background: Adenomyosis, a benign gynecological disorder, is diagnosed with increasing frequency in infertile patients since women delay their first pregnancy. Common symptoms of adenomyosis are dysmenorrhea and heavy menstrual bleeding (HMB), resulting in poor quality of life. Elagolix, the oral GnRH antagonist, acts by reducing the occurrence of ectopic endometrial implants in the myometrium. It diminishes uterine volume, reduces dysmenorrhea and heavy bleeding, and improves fertility outcomes. Dienogest, a synthetic oral progestin highly selective for progesterone receptors, reduces the painful symptoms in women with adenomyosis. The aim or this study was to compare the effect of Elagolix with Dienogest in the treatment of symptomatic adenomyosis.

Methods: This randomized controlled trial was conducted in the department of reproductive endocrinology and infertility, Bangabandhu Sheikh Mujib medical university (BSMMU), Dhaka, from January 2024 to December 2024. A total of 58 participants with symptomatic adenomyosis were randomly assigned to 2 groups (n=29). Each group received either Elagolix (200 mg) or Dienogest (2 mg) once daily for 3 months.

Results: Compared between the two groups, post-treatment mean changes of VAS score (6.25±1.83 vs 4.84±1.56), hemoglobin (-1.21±0.97 vs-0.20±0.56), and median uterine volume (5.1 vs 1.2) were significantly higher in the Elagolix group than the Dienogest group. HMB was also significantly reduced (3.7% vs 23.1%) in the Elagolix than the Dienogest group after 3 months of treatment.

Conclusion: Elagolix significantly reduced VAS score, HMB, and uterine volume in symptomatic adenomyosis compared to Dienogest.

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References

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Published

2025-06-26

How to Cite

Jubaida, U., Deeba, F., Ishrat, S., Anwary, S. A., Sultana, R., Alamgir, C. F., Darmini, M., & Banu, J. (2025). Effect of Elagolix in comparison to Dienogest in the treatment of symptomatic adenomyosis. International Journal of Reproduction, Contraception, Obstetrics and Gynecology, 14(7), 2267–2273. https://doi.org/10.18203/2320-1770.ijrcog20251977

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Original Research Articles