Evaluation of the relationship between thyroid hormones and endometriosis: a clinical investigation

Morteza Sanei Taheri; Majid Valiyan Boroujeni; Zahra Mahboubi Fouladi; Shahla Noori Ardebili; Samaneh Chegeni; Yashar Moharamzad; Simin Abniki; Sara Hasanzadeh

doi:10.18203/2320-1770.ijrcog20252708

Authors

Morteza Sanei Taheri Department of Radiology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Majid Valiyan Boroujeni Department of Radiology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Zahra Mahboubi Fouladi Department of Radiology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Shahla Noori Ardebili Department of Gynecology and Laparoscopy, Atieh Hospital, Tehran, Iran
Samaneh Chegeni Department of Medical Genetics, Faculty of medical Sciences, Tarbiat Modares University, Tehran, Iran
Yashar Moharamzad Department of Radiology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Simin Abniki Department of Radiology, Shohahada Hospital, Tehran, Iran
Sara Hasanzadeh Mayo Clinic, 200 First Street SW, Rochester, Minnesota, United States of America

DOI:

https://doi.org/10.18203/2320-1770.ijrcog20252708

Keywords:

Adhesion, Anti-TPO, Endometriosis, Thyroid hormones, Ultrasound markers

Abstract

Background: Endometriosis is a chronic gynecological condition that affects reproductive-aged women. This study evaluated the correlation between thyroid hormone levels and endometriosis severity.

Methods: A cross-sectional study was conducted at Shohada Tajrish Hospital and Atieh Hospital from September 2024 to April 2025. Participants diagnosed with endometriosis underwent clinical, ultrasound, and thyroid hormone assessments. Statistical analyses were used to explore correlations between hormone levels and endometriosis severity.

Results: Significant associations were found between anti-TPO levels and UBESS stage 2. Pain severity was higher in moderate disease. However, TSH, T3, and Free T4 levels showed no significant correlations with disease stage or pain severity. Adhesion levels were associated with nodule presence and uterosacral ligament thickness.

Conclusions: Elevated anti-TPO levels may indicate autoimmune involvement in moderate endometriosis. Structural markers on ultrasound, such as nodule count and USL thickness, may predict disease severity.

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References

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