Demographic and clinicopathologic profile of malignant epithelial ovarian tumors: an experience from a tertiary cancer care centre in Bangalore, South India

Aruna E. Prasad, Manjunath I. Nandennavar, M. S. Ganesh, Shashidhar V. Karpurmath, Jahnavi Hatti


Background: Ovarian cancer is fast emerging as the leading cancer of the female genital tract. It is the second most common gynecological malignancy in India, but has poor outcomes making it the leading cause of gynecologic cancer related deaths. There is a paucity of data regarding demographic details, patterns of care and outcomes of ovarian epithelial malignancies in India. This is a study to evaluate the demographic details, clinical profile and pathology details of epithelial ovarian cancer registering in atertiary cancer center in Bangalore, Karnataka, India.

Methods: This is a retrospective study of the case records of patients diagnosed with epithelial ovarian cancer from January 2012 to December 2014.

Results: Malignantovarian tumors constituted 5.6% of all malignancies in women. 84 cases were of epithelial origin constituting 64.4% of all malignant ovarian tumors. 58% of patients were from Karnataka and 25% were from West Bengal. 27% underwent suboptimal surgery outside at presentation. The median age at presentation was 51 years. Most of the patients were parous (25% were para 2 and 3). 5% patients were nulliparous. Pain abdomen (39%) and abdominal distension/ bloating (16%) were the most common symptoms. 75% of these cases presented in III-IV stage. Method of diagnosis was: primary surgery and Biopsy of mass (50%), fine needle aspiration cytology of mass or ascites/ pleural effusion (40%), and diagnostic laparoscopy in (9.5%) of the patients. The most common histological variants were serous cystadenocarcinoma (32%) and mucinous adenocarcinoma (15%).

Conclusions: Majority of the patients presented with vague nonspecific abdominal complaints which leads to delay in diagnosis. Most of the patients presented in advanced stage of the disease. Delay in diagnosis and improper management prior to registering in tertiary cancer centre was common. There is a need to improve awareness regarding ovarian cancer in general population and also primary care physician.


Demographic details, Ovarian cancer, Pathology, South India

Full Text:



Torre LA, Bray F, Siegel RL, Ferlay J, Lortet- Tiulent J, Jemal A. Global cancer statistics 2012. CA Cancer J Clin. 2015;65:85-108.

Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M et al. Cancer incidence and mortality worldwide- Sources, methods and major patterns in GLOBOCAN 2012. Int J cancer. 2015;136;359-86.

Consolidated report of Population Based Cancer Registries 2012-2014. National Cancer Registry Program. Indian Council of Medical Research. Bangalore; 2016.

Nandagudi S, Shalini S, Suman G, Srekantaiah P, Aleyamma M. Changing Trends in Incidence of Ovarian Cancer - the Indian Scenario. Asian Pacific J Cancer Prev. 2009;10:1025-30.

Jemal A, Siegel R, Ward E, Murray T, Xu J, Smigal C et al. Cancer statistics, 2006. CA Cancer J Clin. 2006;56:106-30.

Stuart GC, Kitchener H, Bacon M, du Bois A, Friedlander M, Ledermann J, et al. Gynecologic Cancer Inter Group (GCIG) consensus statement on clinical trials in ovarian cancer: report from the Fourth Ovarian Cancer Consensus Conference. Int J Gynecol Cancer. 2011;21:750-5.

Siegel RL, Miller DK, Jemal A. Cancer statistics, 2016. CA Cancer J Clin. 2016;66:7-30.

Paes MF, DaltoƩ RD, Madeira KP, Rezende LC, Sirtoli GM, Herlinger AL et al. A retrospective analysis of clinicopathological and prognostic characteristics of ovarian tumors in the State of Espƭrito Santo, Brazil. J Ovarian Res. 2011;4:14.

Goodman MT, Shvetsov YB. Incidence of ovarian, fallopian and primary peritoneal carcinomas in the United States 1995-2004. Cancer Epidemiol Biomarkers Prev. 2009;18:132-9.

Garg R, Singh S, Rani R, Agarwal M, Rajvanshi R. A Clinicopathological Study of Malignant Ovarian Tumors in India. J South Asian Feder Menopause Soc. 2014:2:9-11.

Basu P, De P, Mandal S, Ray K, Biswas J. Study of 'patterns of care' of ovarian cancer patients in a specialized cancer institute in Kolkata, eastern India. Indian J Cancer. 2009;46:28-33.

Saini SK, Srivastava S, Singh Y, Dixit AK, Prasad SN. Epidemiology of Epithelial ovarian cancer, a single institution-based study in India. Clin Cancer Invest J. 2016;5:20-4.

Risch HA, Marrett LD, Howe GR. Parity, contraception, infertility, and the risk of epithelial ovarian cancer. Am J Epidemiol. 1994;140:585-97.

Hankinson SE, Colditz GA, Hunter DJ, Willett WC, Stampfer MJ, Rosner B et al. A prospective study of reproductive factors and risk of epithelial ovarian cancer. Cancer. 1995;76:284-90.

Hiremath PB, Bahubali G, Meenal C, Narvekara S, Bobby NM. Clinical Profile and Pathology of Ovarian Tumor. Int J Biol Med Res. 2012;3:1743-46.

Murthy NS, Shalini S, Suman G, Srekantaiah P, Mathew A. Changing Trends in Incidence of Ovarian Cancer- The Indian Scenario. Asian Pacific J Cancer Prev. 2009;10:1025-30.

Mallath MK, Taylor DG, Badwe R, Rath G, Shanta V, Pramesh CS et al. The growing burden of cancer in India: epidemiology and social context. Lancet Oncol. 2014;15(6):205-12.

Gajjar K, Ogden G, Mujahid MI, Razvi K. Symptoms and risk factors of ovarian cancer: A survey in primary care. ISRN Obstet Gynecol; Article ID 754197, 2012.

Carney ME, Lancaster JM, Ford C, Tsodikov A, Wiggins C. A population-based study of patterns of care for ovarian cancer: Who is seen by a gynecologic oncologist and who is not? Gynecol Oncol. 2002;84:36-42.