Failed methotrexate therapy in a cesarean scar ectopic pregnancy:  a case report

Rania E. Belal; Eman Mohammed Abbashar; Acha Assmanni Adam

doi:10.18203/2320-1770.ijrcog20253106

Authors

Rania E. Belal Specialist of Obstetrics and Gynecology, Saudi Arabia
Eman Mohammed Abbashar Membership of the Royal College of Obstetricians and Gynaecologists, UK
Acha Assmanni Adam Consultant of Obstetrics and Gynecology, Saudi Arabia

DOI:

https://doi.org/10.18203/2320-1770.ijrcog20253106

Keywords:

Cesarean scar ectopic pregnancy, Methotrexate failure, Conservative treatment, Surgical management, Obstetric haemorrhage, Fertility preservation

Abstract

Cesarean scar ectopic pregnancy (CSEP) is a rare and potentially life-threatening early pregnancy complication associated with prior cesarean section scars, where early detection and treatment are critical to reducing maternal morbidity. Methotrexate (MTX) therapy is a standard conservative approach, but may fail in some instances. We report a case of a 29-year-old woman (gravida 5, para 4) who presented at seven weeks' gestation with mild vaginal bleeding. Transvaginal ultrasound (TVUS) confirmed a non-viable CSEP, and ultrasound-guided intra-sac MTX injection was attempted as conservative management. Despite treatment, the patient developed worsening haemorrhage requiring emergency surgical intervention. Intraoperative findings revealed significant vascularity at the implantation site, and surgical excision of the ectopic pregnancy was performed with preservation of the uterus. The postoperative course was uneventful. This case highlights the limitations of MTX in treating CSEP. It emphasizes the importance of early recognition of treatment failure and prompt surgical management to prevent severe maternal morbidity and preserve reproductive potential.

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