Invasive mole presenting as abnormal uterine bleeding: a case report and review of literature
DOI:
https://doi.org/10.18203/2320-1770.ijrcog20253115Keywords:
Invasive mole, Gestational trophoblastic neoplasia, Chemotherapy, Case reportAbstract
Invasive mole is a type of gestational trophoblastic neoplasia (GTN). It usually occurs after a molar or non-molar pregnancy. Here we would like to present a 47-year-old nulligravida lady who does not give any history of antecedent pregnancy. She had symptoms of abnormal uterine bleeding (AUB) and came to the causality with heavy flow. Beta hCG was very high and MRI showed uterine tumor. She underwent total abdominal hysterectomy with bilateral salpingoopherectomy which showed invasive mole FIGO stage II. Her WHO prognostic score was 9 and hence she received EMA-CO regimen of chemotherapy. GTN can present in different ways, even without a history of previous pregnancy. In such situations a high level of suspicion and a simple Beta hCG level can clinch the diagnosis.
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References
Tehranian A, Ghahghaei-Nezamabadi A, Vahid dastjerdi M, Esalatmanesh S, Seifollahi A. Presentation invasive mole after normal pregnancy: a very rare case report. Case Rep Clin Pract. 2023;8(4):155-8. DOI: https://doi.org/10.18502/crcp.v8i4.14575
Syamel Muhammad. Invasive Mole with Impending Uterine Rupture: A Case Report. Journal of Midwifery. 2022; 7(2). DOI: https://doi.org/10.25077/jom.7.2.14-18.2022
Soheila Aminimoghaddam, Andisheh Maghsoudnia. Unusual Presentation of Invasive Mole: A Case Report. J Reprod Infertil. 2017 Jan-Mar;18(1):205–209.
Balagopal P, Pandey M, Chandramohan K, Somanathan T, Kumar A. Unusual presentation of choriocarcinoma. World J Surg Oncol. 2003;1(1):4. DOI: https://doi.org/10.1186/1477-7819-1-4
Ismail S, Mikhael K, Salloum N, Alshehabi Z. An invasive mole with pulmonary metastases in a 55‑year‑old postmenopausal Syrian woman: a case report and review of the literature. Med Case Reports. 2021;15:13. DOI: https://doi.org/10.1186/s13256-020-02630-3
Amany A. Fathaddin. Invasive hydatidiform mole mimicking ectopic pregnancy: a case report and literature. Am J Case Rep. 2025;26:946388. DOI: https://doi.org/10.12659/AJCR.946388
Qian J, Xu S, Chen L. Cornual invasive hydatidiform mole: a rare case report and literature review. BMC Women’s Health. 2023;23:566. DOI: https://doi.org/10.1186/s12905-023-02727-z
Sankhae DD, Somalwar S, Jiandani F, Jain S, Shetty A. Invasive Mole Mimicking Abnormal Uterine Bleeding: A Case Report. Cureus. 2023;15(2):35195. DOI: https://doi.org/10.7759/cureus.35195
Lurain JR. Gestational trophoblastic disease: Epidemiology, pathology, clinical presentation and diagnosis of gestational trophoblastic disease, and management of hydatidiform mole. Am J Obstet Gynecol. 2010;203(6):531-39. DOI: https://doi.org/10.1016/j.ajog.2010.06.073
Harsono AB, Hidayat YM, Winarno GNA, Nisa AS, Alkaff FF. A Case of Rapid Transformation from Hydatidiform Mole to Invasive Mole: The Importance of b-hCG (Human Chorionic Gonadotropin) Serum Levels in Follow-Up Evaluation. Am J Case Rep. 2021;22:931156. DOI: https://doi.org/10.12659/AJCR.931156
Xu L, Feng M, Cai J and Li H. Case report: Conservative treatment for fertility preservation in a woman with hemoperitoneum due to an invasive mole. Front. Oncol. 2022;12:1019082. DOI: https://doi.org/10.3389/fonc.2022.1019082