A comparative study on MgSO₄ and nifedipine as acute tocolytic agents in preterm labour
DOI:
https://doi.org/10.18203/2320-1770.ijrcog20252927Keywords:
Preterm labour, Tocolysis, Magnesium sulphate, Nifedipine, Neonatal outcomeAbstract
Background: Preterm labour is a major cause of neonatal morbidity and mortality. Tocolysis helps delay delivery, allowing time for antenatal corticosteroids and in-utero transfer. Magnesium sulphate (MgSO4) and nifedipine are commonly used agents, but comparative evidence is limited. To compare the efficacy and safety of MgSO₄ and nifedipine as acute tocolytics in preterm labour.
Methods: This randomized controlled trial at a tertiary care centre - GMC Akola, enrolled 100 women between 28–34 weeks of gestation with preterm labour. Participants were randomly allocated to receive either MgSO₄ (loading dose 4 g IV, followed by 1 g/hr infusion) or oral nifedipine (10 mg every 20 min up to 3 doses, then 20 mg every 4-6 hrs for 24 hrs). Outcomes assessed were uterine quiescence, prolongation of pregnancy ≥48 hrs, maternal side effects, and neonatal outcomes.
Results: Labour was arrested in 92% of women treated with MgSO₄ and 90% with nifedipine. MgSO₄ achieved slightly higher rates of uterine quiescence and prolongation beyond 48 hrs. NICU admissions were lower with MgSO₄ (38% vs 44%), as was neonatal mortality (10% vs 14%). Side effects were mild and comparable: hot flushes/lethargy with MgSO₄ and tachycardia/headache with nifedipine. No serious adverse events occurred.
Conclusion: Both MgSO₄ and nifedipine are effective and safe tocolytic agents. MgSO₄ offers a marginal advantage in prolonging gestation and provides fetal neuroprotection, whereas nifedipine is simpler to administer and cost-effective in low-resource settings.
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References
World Health Organization. Preterm birth. Available at: https://www.who.int/news-room/fact-sheets/ detail/preterm-birth. Accessed on 16 January 2025.
National Library of Medicine. Magnesium sulfate. Available at: https://www.ncbi.nlm.nih.gov/ books/NBK554553/. Accessed on 16 January 2025.
Wikipedia. Magnesium sulfate. Available at: https://en.wikipedia.org/wiki/Magnesium_sulfate. Accessed on 16 January 2025.
National Library of Medicine. Nifedipine. Available at: https://www.ncbi.nlm.nih.gov/books/NBK537052/. Accessed on 16 January 2025.
National Library of Medicine. Preterm labor. Available at: https://www.ncbi.nlm.nih.gov/books/NBK536939/. Accessed on16 January 2025.
Ambedkar D, Kushwaha V. A comparative study between nifedipine and magnesium sulfate for treatment of preterm labor. Eur J Mol Clin Med. 2022;9:123-9.
Tabassum S, Shahzadi U, Khalid A. Comparative study of efficacy of magnesium sulfate and nifedipine in suppression of preterm labour. Pak J Med Health Sci. 2016;10:1307-11.
Nassar AH, Usta IM. Magnesium sulfate compared with nifedipine for acute tocolysis of preterm labor: a randomized controlled trial. Obstet Gynecol. 2007;110:1170-1. DOI: https://doi.org/10.1097/01.AOG.0000288511.26365.48
Faisal JA, Kanwal S, Inayat FC, Jawad Z, Shabana N, Zafar I. Comparison of magnesium sulfate and nifedipine for the management of preterm labour. Pak J Med Health Sci. 2020;14:534-7.
Shahbazian N, Saadati N, Mahdavi M. Comparison of magnesium sulfate and nifedipine in prevention of preterm labor. J Mol Biol Res. 2020;10:1-2.
Wu Y, Wang DJ, Zhang Y, Zhang YX, Zhang R. Regulation of magnesium sulfate combined with nifedipine and labetalol on disease-related molecules in serum and placenta in the treatment of preeclampsia. Eur Rev Med Pharmacol Sci. 2020;24:5062-70.
Mousa AA, Mohamed MA, Radwan MS, El Sayed KF. A comparative study between nifedipine, ritodrine and magnesium sulfate as tocolytics in cases of preterm labor and their effect on utero placental perfusion. Egypt J Hosp Med. 2019;75:2878-87. DOI: https://doi.org/10.21608/ejhm.2019.33362
Nikbakht R, Moghadam MT, Ghane’ee H. Nifedipine compared to magnesium sulfate for treating preterm labor: a randomized clinical trial. Iran J Reprod Med. 2014;12:145-50.
Bhat S, Jain A, Sunil KS. Nifedipine versus magnesium sulfate in the management of preterm labour: a randomised controlled trial. Indian J Obstet Gynecol Res. 2023;10:460-8. DOI: https://doi.org/10.18231/j.ijogr.2023.088
Shahbazian N, Saadati N, Mahdavi M. Comparison of magnesium sulfate and nifedipine in prevention of preterm labor. J Mol Biol Res. 2020;10:1-2. DOI: https://doi.org/10.5539/jmbr.v10n1p12
Lyell DJ, Pullen K, Campbell L, Ching S, Druzin ML, Chitkara U, et al. Magnesium sulfate compared with nifedipine for acute tocolysis of preterm labor: a randomized controlled trial. Obstet Gynecol. 2007;110:61-7.
Nikbakht R, Moghadam MT, Ghane H. Nifedipine compared to magnesium sulphate for treating preterm labour: a randomized clinical trial. Iran J Reprod Med. 2014;12:145-50.
Khooshideh M, Rahmati J, Teimoori B. Nifedipine versus magnesium sulfate for treatment of preterm labor: comparison of efficacy and adverse effects in a randomized controlled trial. Shiraz E Med J. 2017;18:46875. DOI: https://doi.org/10.5812/semj.46875
Glock JL, Morales WJ. Efficacy and safety of nifedipine versus magnesium sulfate in the management of preterm labor: a randomized study. Am J Obstet Gynecol. 1993;169:960-4. DOI: https://doi.org/10.1016/0002-9378(93)90035-H
Conde-Agudelo A, Romero R, Kusanovic JP. Nifedipine in the management of preterm labor: a systematic review and meta-analysis. Am J Obstet Gynecol. 2011;204:134. DOI: https://doi.org/10.1016/j.ajog.2010.11.038
Lyell DJ, Pullen K, Campbell L, Ching S, Druzin ML, Chitkara U, et al. Magnesium sulfate compared with nifedipine for acute tocolysis of preterm labor: a randomized controlled trial. Obstet Gynecol. 2007;110:61-7. DOI: https://doi.org/10.1097/01.AOG.0000269048.06634.35
Grimes DA, Nanda K. Magnesium sulfate tocolysis: time to quit. Obstet Gynecol. 2006;108:986-9. DOI: https://doi.org/10.1097/01.AOG.0000236445.18265.93
American College of Obstetricians and Gynecologists. Magnesium sulfate before anticipated preterm birth for neuroprotection. Committee Opinion No. 455. Obstet Gynecol. 2010;115:669-71. DOI: https://doi.org/10.1097/AOG.0b013e3181d4ffa5