Beyond conduction defects: fetal myocarditis as a rare cardiac manifestation in anti-Ro/La positive lupus pregnancy

Authors

  • Sreeja Mogiligari Department of Clinical Immunology and Rheumatology, ESIC Medical College and Super Speciality Hospital, Sanathnagar, Hyderabad, Telangana, India
  • Vijaya P. Parimi Department of Clinical Immunology and Rheumatology, ESIC Medical College and Super Speciality Hospital, Sanathnagar, Hyderabad, Telangana, India

DOI:

https://doi.org/10.18203/2320-1770.ijrcog20253916

Keywords:

Fetal myocarditis, SLE, MTP

Abstract

Fetal myocarditis is an uncommon yet potentially fatal complication of maternal systemic lupus erythematosus (SLE), in contrast to the more recognized congenital heart block (CHB). We report a case of a fetal myocarditis in young female with lupus and anti-Ro/SSA and anti-La/SSB antibodies positivity. This case emphasizes the importance of early fetal monitoring in lupus pregnancies and highlights the complex role of maternal auto antibodies in fetal cardiac inflammation.

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References

Izmirly PM, Saxena A, Kim MY, Wang D, Sahl SK, Llanos C, et al. Maternal and fetal factors associated with mortality and morbidity in a multi-racial/ethnic registry of anti-SSA/Ro-associated cardiac neonatal lupus. Circulation. 2011;124(18):1927-35. DOI: https://doi.org/10.1161/CIRCULATIONAHA.111.033894

Friedman DM, Kim MY, Copel JA, Davis C, Phoon CK, Glickstein JS, et al. Utility of cardiac monitoring in fetuses at risk for congenital heart block: the PR Interval and Dexamethasone Evaluation (PRIDE) prospective study. Circulation. 2008;117(4):485-93. DOI: https://doi.org/10.1161/CIRCULATIONAHA.107.707661

Buyon JP, Clancy RM, Friedman DM. Autoimmune-associated congenital heart block: integration of clinical and research clues in the management of the maternal/fetal dyad at risk. J Intern Med. 2009;265(6):653-62. DOI: https://doi.org/10.1111/j.1365-2796.2009.02100.x

Hoxha A. New insights into the pathogenesis and treatment of autoimmune congenital heart block. Autoimmun Rev. 2020;19(5):102502.

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Published

2025-11-27

How to Cite

Mogiligari, S., & Parimi, V. P. (2025). Beyond conduction defects: fetal myocarditis as a rare cardiac manifestation in anti-Ro/La positive lupus pregnancy. International Journal of Reproduction, Contraception, Obstetrics and Gynecology, 14(12), 4390–4392. https://doi.org/10.18203/2320-1770.ijrcog20253916

Issue

Section

Case Reports