Beyond conduction defects: fetal myocarditis as a rare cardiac manifestation in anti-Ro/La positive lupus pregnancy
DOI:
https://doi.org/10.18203/2320-1770.ijrcog20253916Keywords:
Fetal myocarditis, SLE, MTPAbstract
Fetal myocarditis is an uncommon yet potentially fatal complication of maternal systemic lupus erythematosus (SLE), in contrast to the more recognized congenital heart block (CHB). We report a case of a fetal myocarditis in young female with lupus and anti-Ro/SSA and anti-La/SSB antibodies positivity. This case emphasizes the importance of early fetal monitoring in lupus pregnancies and highlights the complex role of maternal auto antibodies in fetal cardiac inflammation.
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References
Izmirly PM, Saxena A, Kim MY, Wang D, Sahl SK, Llanos C, et al. Maternal and fetal factors associated with mortality and morbidity in a multi-racial/ethnic registry of anti-SSA/Ro-associated cardiac neonatal lupus. Circulation. 2011;124(18):1927-35. DOI: https://doi.org/10.1161/CIRCULATIONAHA.111.033894
Friedman DM, Kim MY, Copel JA, Davis C, Phoon CK, Glickstein JS, et al. Utility of cardiac monitoring in fetuses at risk for congenital heart block: the PR Interval and Dexamethasone Evaluation (PRIDE) prospective study. Circulation. 2008;117(4):485-93. DOI: https://doi.org/10.1161/CIRCULATIONAHA.107.707661
Buyon JP, Clancy RM, Friedman DM. Autoimmune-associated congenital heart block: integration of clinical and research clues in the management of the maternal/fetal dyad at risk. J Intern Med. 2009;265(6):653-62. DOI: https://doi.org/10.1111/j.1365-2796.2009.02100.x
Hoxha A. New insights into the pathogenesis and treatment of autoimmune congenital heart block. Autoimmun Rev. 2020;19(5):102502.