An observational study to classify causes of abnormal uterine bleeding according to PALM-COEIN classification

Authors

  • Urmish Patel Department of Obstetrics and Gynaecology, Government Medical College, Surat, Gujarat, India
  • Nilam Prajapati Department of Obstetrics and Gynaecology, Government Medical College, Surat, Gujarat, India
  • Bhoomika Chaudhary Department of Obstetrics and Gynaecology, Government Medical College, Surat, Gujarat, India
  • Madhuli Mayani Department of Obstetrics and Gynaecology, Government Medical College, Surat, Gujarat, India
  • Ameena Shaikh Department of Obstetrics and Gynaecology, Government Medical College, Surat, Gujarat, India
  • Nitinkumar Hadiya Department of Obstetrics and Gynaecology, Government Medical College, Surat, Gujarat, India

DOI:

https://doi.org/10.18203/2320-1770.ijrcog20252903

Keywords:

Abnormal uterine bleeding, Adenomyosis, Histopathology, Leiomyoma, Medical management, PALM-COEIN, Surgical intervention

Abstract

Background: Abnormal uterine bleeding (AUB) is a frequent gynecological complaint affecting women of all ages, significantly impacting quality of life. To standardize its diagnosis and management, the International Federation of Gynecology and Obstetrics (FIGO) introduced the PALM-COEIN classification system, which categorizes AUB into structural and non-structural causes. To classify AUB according to PALM-COEIN classification, to know associated risk factors, to know their demography and modality of treatment required.

Methods: This observational cross-sectional study was conducted in the Department of Obstetrics and Gynaecology at New Civil Hospital, Surat, from May 2024 to April 2025. Approval was obtained from the Institutional Research Review Committee (Approval ID: GMCS/RRC-2/13433/24).

A total of 200 consenting women with AUB (non-pregnancy related) were included. Exclusion criteria: pregnancy-related bleeding or refusal to consent. Detailed clinical history, examination, investigations, imaging and biopsy when indicated were done. Classification was as per PALM-COEIN. Treatment included medical or surgical modalities. Response was assessed over a 3-month follow-up.

Results: The most common cause of AUB was adenomyosis (AUB-A, 33%), followed by leiomyoma (AUB-L, 30.5%) and ovulatory dysfunction (AUB-O, 14%). Among non-structural causes, AUB-O was predominant. In this study simple endometrial hyperplasia without atypia in 4 cases and half of those patients improved with medical treatment. Medical management was effective in 64.48% of treated patients, while 65.5% required surgical intervention. Obesity (26%) and thyroid disorders (17.5%) were the most common comorbid risk factors.

Conclusions: The PALM-COEIN classification system was a useful and thorough tool for understanding the causes of AUB, helping to standardize diagnoses, plan better treatments and achieve better results in patient care. It also facilitated effective communication and comparison across clinical and research settings.

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References

Berek JS. Berek, Novak’s Gynecology. 16th ed. Philadelphia: Wolters Kluwer. 2019:131.

Sood M, Devi A, Daher A, Razali S, Nawawi H, Hashim S, et al. Poor correlation of stress levels and menstrual patterns among medical students. J Asian Behav Stud. 2017;2(5):73–8. DOI: https://doi.org/10.21834/jabs.v2i5.221

Awwad JT, Toth TL, Schiff I. Abnormal uterine bleeding in the perimenopause. Int J Fertil Menopausal Stud. 1993;38(5):261-9.

Livingstone M, Fraser IS. Mechanisms of abnormal uterine bleeding. Hum Reprod Update. 2002;8(1):60–7. DOI: https://doi.org/10.1093/humupd/8.1.60

World Health Organization. Research on menopause in the 1990s: report of a WHO scientific group. WHO Technical Report Series No. 866. Geneva: WHO; 1996. Available at: https://apps.who.int/iris. Accessed on 21 March 2025.

American College of Obstetricians and Gynecologists. Management of abnormal uterine bleeding associated with ovulatory dysfunction. Obstet Gynecol. 2013;121(4):891–6.

National Institute for Health and Care Excellence (NICE). Heavy menstrual bleeding: assessment and management (NG88). London: NICE; 2018. Available at: https://www.nice.org.uk/guidance. Accessed on 21 March 2025

Munro MG, Critchley HO, Broder MS, Fraser IS. FIGO Working Group on Menstrual Disorders. FIGO classification system (PALM-COEIN) for causes of abnormal uterine bleeding in nongravid women of reproductive age. Int J Gynaecol Obstet. 2011;113(1):3-13. DOI: https://doi.org/10.1016/j.ijgo.2010.11.011

Sharma A, Dogra Y. Trends of abnormal uterine bleeding in tertiary centre of Shimla hills. J Midlife Health. 2013;4(1):67–8. DOI: https://doi.org/10.4103/0976-7800.109648

Prabhudev P, Sapna IS, Pujar TV, Achala KP. A prospective study on abnormal uterine bleeding with sonological and histopathological correlation in women attending tertiary care hospital. International J Reprod, Cont, Obst Gynecol. 2022;11(1):3023–7. DOI: https://doi.org/10.18203/2320-1770.ijrcog20222789

Mahapatra M, Mishra P, Behera AK. Clinical study of abnormal uterine bleeding and its management. J Obstet Gynaecol India. 2015;65(5):328–31.

Ratnani R, Jain M, Ratnani S. A study of abnormal uterine bleeding in women using PALM-COEIN system. J Clin Diag Res. 2017;11(6):10–4.

Gouri S, Jindal S, Aggarwal N. Clinical spectrum of abnormal uterine bleeding using PALM-COEIN classification. Int J Reprod Contracept Obstet Gynecol. 2016;5(3):626–31.

Goel P, Rathore SB. PALM-COEIN FIGO classification for diagnosis of abnormal uterine bleeding. Sch J App Med Sci. 2016;4(8):2771-3.

Divya A, Nair V, Kumar S. Endometrial hyperplasia: clinical and histological study. Int J Reprod Contracept Obstet Gynecol. 2017;6(8):3569–73.

Singh S, Sahoo S, Das PC. A study of thyroid dysfunction in dysfunctional uterine bleeding. Int J Repr Contracept Obstet Gynecol. 2018;7(3):1002-6. DOI: https://doi.org/10.18203/2320-1770.ijrcog20180881

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Published

2025-09-09

How to Cite

Patel, U., Prajapati, N., Chaudhary, B., Mayani, M., Shaikh, A., & Hadiya, N. (2025). An observational study to classify causes of abnormal uterine bleeding according to PALM-COEIN classification. International Journal of Reproduction, Contraception, Obstetrics and Gynecology, 14(10), 3268–3274. https://doi.org/10.18203/2320-1770.ijrcog20252903

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Original Research Articles