Estimation of shock index and need of blood transfusion in patients with post-partum hemorrhage: an observational study
DOI:
https://doi.org/10.18203/2320-1770.ijrcog20254280Keywords:
Blood transfusion, Postpartum hemorrhage, Shock indexAbstract
Background: Postpartum hemorrhage (PPH) is a leading cause of maternal morbidity and mortality worldwide, especially in low-resource settings. Early detection of hemodynamic instability is critical for timely intervention. The Shock Index (SI), defined as the ratio of heart rate to systolic blood pressure, may serve as a rapid bedside indicator to predict transfusion requirements in PPH.
Methods: This prospective observational study included 120 women with PPH admitted to the Department of Obstetrics and Gynaecology, Government Medical College and Hospital, Akola, Maharashtra, from March 2023 to October 2024. Serial SI measurements at 30, 60 and 120 minutes postpartum were recorded and correlated with blood transfusion requirements, clinical interventions and outcomes. Data were analysed using SPSS version 16, with p<0.05 considered significant.
Results: The mean SI peaked at 60 minutes (1.09±0.25). SI≥0.9 predicted transfusion need with 95% sensitivity and 60% specificity, SI≥1.1 predicted transfusion with 100% sensitivity and 93% specificity and SI≥1.3 predicted massive transfusion (>4 units) with an AUC of 0.97 (sensitivity 94%, specificity 98%). Cesarean deliveries had higher SI (1.26 vs. 0.99) and transfusion rates (88% vs. 56%) than vaginal births (p<0.001).
Conclusions: Shock Index is a simple, non-invasive and reliable marker for early prediction of transfusion need in PPH. Incorporating SI thresholds (≥0.9 for vigilance, ≥1.1 for intervention, ≥1.3 for critical action) into PPH protocols can improve maternal outcomes.
References
Say L, Chou D, Gemmill A, Tunçalp Ö, Moller AB, Daniels J, et al. Global causes of maternal death: a WHO systematic analysis. Lancet Glob Health. 2014;2(6):323-33.
Carroli G, Cuesta C, Abalos E, Gulmezoglu AM. Epidemiology of postpartum haemorrhage: a systematic review. Best Pract Res Clin Obstet Gynaecol. 2008;22(6):999-1012.
World Health Organization. WHO recommendations: Uterotonics for the prevention of postpartum haemorrhage. Geneva: WHO; 2018.
Schorn MN. Measurement of blood loss: review of the literature. J Midwifery Women Health. 2010;55(1):20-7.
Nathan HL, El Ayadi A, Hezelgrave NL, Seed P, Butrick E, Miller S, et al. Shock index: an effective predictor of outcome in postpartum haemorrhage. BJOG. 2015;122(2):268-75.
Allgöwer M, Burri C. "Schockindex". Shock index". Dtsch Med Wochenschr. 1967;92(43):1947-50.
Rady MY, Smithline HA, Blake H, Nowak R, Rivers E. A comparison of the shock index and conventional vital signs to identify acute, critical illness in the emergency department. Ann Emerg Med. 1994;24(4):685-90.
Pacagnella RC, Souza JP, Durocher J, Perel P, Blum J, Winikoff B, et al. A Systematic Review of the Relationship between Blood Loss and Clinical Signs. PLoS ONE. 2013;8(3):57594.
El Ayadi AM, Nathan HL, Seed PT, Butrick EA, Hezelgrave NL, Shennan AH, et al. Vital Sign Prediction of Adverse Maternal Outcomes in Women with Hypovolemic Shock: The Role of Shock Index. PLoS One. 2016;22;11(2):148729.
Nathan HL, Seed PT, Hezelgrave NL, De Greeff A, Lawley E, Anthony J, et al. Shock index thresholds to predict adverse outcomes in maternal hemorrhage and sepsis: A prospective cohort study. Acta Obstet Gynecol Scand. 2019;98(9):1178-86.
Indian Council of Medical Research (ICMR). Ethical guidelines for biomedical research on human participants. New Delhi: ICMR. 2017.
Pan Y, Ding J, Feng J, Pan Z. Utility of shock index for predicting severity of postpartum haemorrhage: A systematic review and meta-analysis. Pak J Med Sci. 2025;41(7):2133-43.
Madar H, Deneux-Tharaux C, Sentilhes L. TRAAP Study Group. Shock index as a predictor of postpartum haemorrhage after vaginal delivery: Secondary analysis of a multicentre randomised controlled trial. BJOG. 2024;131(3):343-52.
Chaudhary M, Maitra N, Sheth T, Vaishnav P. Shock Index in the Prediction of Adverse Maternal Outcome. J Obstet Gynaecol India. 2020;70(5):355-9.
Tanacan A, Fadiloglu E, Unal C, Beksac MS. Importance of shock index in the evaluation of postpartum hemorrhage cases that necessitate blood transfusion. Women Health. 2020;60(9):1070-8.
Oglak SC, Obut M, Tahaoglu AE, Demirel NU, Kahveci B, Bagli I. A prospective cohort study of shock index as a reliable marker to predict the patient's need for blood transfusion due to postpartum hemorrhage. Pak J Med Sci. 2021;37(3):863-8.
Sheldon WR, Blum J, Vogel JP, Souza JP, Gülmezoglu AM, Winikoff B. WHO Multicountry Survey on Maternal and Newborn Health Research Network. Postpartum haemorrhage management, risks and maternal outcomes: findings from the World Health Organization Multicountry Survey on Maternal and Newborn Health. BJOG. 2014;121(1):5-13.
Shields LE, Wiesner S, Klein C, Pelletreau B, Hedriana HL. Use of Maternal Early Warning Trigger tool reduces maternal morbidity. Am J Obstet Gynecol. 2016;214(4):527.
Rojas-Suarez J, Paternina-Caicedo Á, Tolosa JE, Guzmán-Polanía L, Gonzalez N, Pomares F, et al. The impact of maternal anemia and labor on the obstetric Shock Index in women in a developing country. Obstet Med. 2020;13(2):83-7.
World Health Organization. WHO technical brief: Early warning indicators for postpartum haemorrhage. Geneva: WHO. 2023.