Association of ovarian volume with insulin resistance in PCOS patients
DOI:
https://doi.org/10.18203/2320-1770.ijrcog20254258Keywords:
Insulin resistance, Ovarian volume, Polycystic ovary syndromeAbstract
Background: Polycystic ovary syndrome (PCOS) is a common endocrine disorder in women, characterized by hyperandrogenism, menstrual irregularities, polycystic ovarian morphology, and often associated with insulin resistance. The purpose of this study was to assess the association between insulin resistance and ovarian volume in PCOS patients, comparing women with ovarian volume >10 cc to those with ≤10 cc. The aim of the study was to evaluate the association between ovarian volume and insulin resistance among patients diagnosed with polycystic ovary syndrome (PCOS).
Methods: This comparative cross-sectional study at the department of obstetrics and gynecology, ICMH, Dhaka (October 2022-September 2023) included 66 women with PCOS (18-35 years), divided by ovarian volume into Group A (>10 cc, n=34) and Group B (≤10 cc, n=32). Fasting glucose, insulin, HOMA-IR, hirsutism, BMI, and waist-to-hip ratio were assessed, analyzed with SPSS v27 (p<0.05).
Results: In 66 PCOS patients, groups were similar in age, BMI, waist-to-hip ratio, menarche, parity, and Ferriman-Gallwey score (all p>0.05); HOMA-IR was higher in group A (4.83 versus 3.59; p=0.012), correlated with ovarian volume (r=0.685, p<0.001), and HOMA-IR ≥3.8 increased odds of ovarian volume >10 cc (67.6% versus 21.9%; OR=7.468; 95% CI=2.476-22.522; p<0.001).
Conclusions: Higher insulin resistance (HOMA-IR ≥3.8) is significantly associated with larger ovarian volume (>10 cc) in PCOS patients, suggesting ovarian volume as a potential indicator of insulin resistance.
References
Choudhury AA, Rajeswari VD. Polycystic ovary syndrome (PCOS) increases the risk of subsequent gestational diabetes mellitus (GDM): a novel therapeutic perspective. Life Sci. 2022;310:121069.
World Health Organization. Polycystic ovary syndrome. Geneva: WHO; 2023. Available from: https://www.who.int/news-room/fact-sheets/detail/polycystic-ovary-syndrome. Accessed on 3 June 2025.
Rao M, Broughton KS, LeMieux MJ. Cross-sectional study on the knowledge and prevalence of PCOS at a multiethnic university. Progress Prevent Med. 2020;5(2):e0028.
Ganie MA, Rashid A, Sahu D, Nisar S, Wani IA, Khan J. Prevalence of polycystic ovary syndrome (PCOS) among reproductive age women from Kashmir valley: a cross‐sectional study. Int J Gynecol Obstet. 2020;149(2):231-6.
Fatema K, Das TR, Kazal RK, Mahamood S, Pervin HH, Noor F, et al. Prevalence and characteristics of polycystic ovarian syndrome in women attending in outpatient department of obstetrics and gynecology of Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh. Int J Reprod Contracept Obstet Gynecol. 2021;10(3):830-6.
Bozdag G, Mumusoglu S, Zengin D, Karabulut E, Yildiz BO. The prevalence and phenotypic features of polycystic ovary syndrome: a systematic review and meta-analysis. Hum Reprod. 2016;31(12):2841-55.
Meier RK. Polycystic ovary syndrome. Nurs Clin North Am. 2018;53(3):407-20.
Palomba S, Daolio J, La Sala GB. Oocyte competence in women with polycystic ovary syndrome. Trends Endocrinol Metab. 2017;28(3):186-98.
Louwers YV, Laven JS. Characteristics of polycystic ovary syndrome throughout life. Ther Adv Reprod Health. 2020;14:2633494120911038.
Azziz R, Carmina E, Chen Z, Dunaif A, Laven JS, Legro RS, et al. Polycystic ovary syndrome. Nat Rev Dis Prim. 2016;2(1):1-8.
Heidarzadehpilehrood R, Pirhoushiaran M, Abdollahzadeh R, Binti Osman M, Sakinah M, Nordin N, et al. A review on CYP11A1, CYP17A1, and CYP19A1 polymorphism studies: candidate susceptibility genes for polycystic ovary syndrome (PCOS) and infertility. Genes. 2022;13(2):302.
Hayes MG, Urbanek M, Ehrmann DA, Armstrong LL, Lee JY, Sisk R, et al. Genome-wide association of polycystic ovary syndrome implicates alterations in gonadotropin secretion in European ancestry populations. Nat Commun. 2015;6(1):7502.
Dumesic DA, Padmanabhan V, Chazenbalk GD, Abbott DH. Polycystic ovary syndrome as a plausible evolutionary outcome of metabolic adaptation. Reproductive Biol Endocrinol. 2022;20(1):12.
Galluzzo A, Amato MC, Giordano C. Insulin resistance and polycystic ovary syndrome. Nutr Metab Cardiovasc Dis. 2008;18(7):511-8.
Diamanti-Kandarakis E. Polycystic ovarian syndrome: pathophysiology, molecular aspects and clinical implications. Exp Rev Mol Med. 2008;10:e3.
Chun S. Serum luteinizing hormone level and luteinizing hormone/follicle-stimulating hormone ratio but not serum anti-Müllerian hormone level is related to ovarian volume in Korean women with polycystic ovary syndrome. Clin Exp Reprod Med. 2014;41(2):86.
Dewailly D, Lujan ME, Carmina E, Cedars MI, Laven J, Norman RJ, et al. Definition and significance of polycystic ovarian morphology: a task force report from the Androgen Excess and Polycystic Ovary Syndrome Society. Hum Reprod Update. 2014;20(3):334-52.
Mansour A, Hashemi Taheri AP, Moradi B, Mohajeri-Tehrani MR, Qorbani M, Ghorbani Pashakolaee S, et al. Ovarian volume, not follicle count, is independently associated with androgens in patients with polycystic ovary syndrome. BMC Endocr Disord. 2022;22(1):298.
Villa P, Rossodivita A, Sagnella F, Moruzzi MC, Mariano N, Lassandro AP, et al. Ovarian volume and gluco‐insulinaemic markers in the diagnosis of PCOS during adolescence. Clin Endocrinol. 2013;78(2):285-90.
Guastella E, Longo RA, Carmina E. Clinical and endocrine characteristics of the main polycystic ovary syndrome phenotypes. Fertil Steril. 2010;94(6):2197-201.
Bhat K, Bhandari M, Garg V. Prostate specific antigen: a diagnostic marker in polycystic ovarian syndrome. J Clin Diagn Res. 2019;13(1).
Gencer G, Serin AN, Gencer K. Comparison of insulin resistance and overian volume in patients with polycystic ovary syndrome with and without Hashimoto. Res Square. 2022.
Roos N, Kieler H, Sahlin L, Ekman-Ordeberg G, Falconer H, Stephansson O. Risk of adverse pregnancy outcomes in women with polycystic ovary syndrome: population based cohort study. BMJ. 2011;343.
Hong SH, Sung YA, Hong YS, Jeong K, Chung H, Lee H. Polycystic ovary morphology is associated with insulin resistance in women with polycystic ovary syndrome’. Clin Endocrinol. 2017;87(4):375-80.
Reid SP, Kao CN, Pasch L, Shinkai K, Cedars MI, Huddleston HG. Ovarian morphology is associated with insulin resistance in women with polycystic ovary syndrome: a cross sectional study. Fertil Res Pract. 2017;3(1):8.
Neoklis A, Anastasia K, Damianaki K, Nikolaos D, Markantes G, Papadopoulos V, et al. Polycystic ovarian morphology is associated with hyperandrogenemia and insulin resistance in women with polycystic ovary syndrome (PCOS). J Steroids Horm Sci. 2016;7(1):1-5.
Downloads
Published
How to Cite
Issue
Section
