Giant lipoleiomyoma-an intimidating entity: case report and literature review
DOI:
https://doi.org/10.18203/2320-1770.ijrcog20171449Keywords:
Intraperitoneal, Leiomyoma, Lipoleiomyoma, Liposarcoma, Perimenopausal, Uterine neoplasmAbstract
Lipomatous uterine neoplasms are extremely uncommon lesions with a reported incidence of 0.01% to 0.2%. These lesions frequently pose a diagnostic challenge not only for the clinician but also for radiologists and pathologists alike. Diagnosis requires a multidisciplinary as well as multimodality approach. A 42-year-old peri-menopausal lady presented with abdominal distension, pain and irregular menstrual bleeding. On radiology, an intra-abdodominal hetergenous mass was seen suggestive of neoplastic etiology, possibly intraperitoneal liposarcoma. Microscopy revealed numerous adipocyte clusters intersecting the smooth muscle bundles, diagnostic of lipoleiomyoma. The present case is unusual as the patient had both intramural and broad ligament lipoleiomyoma. Through the present case we revisit clinical and morphological findings of lipoleiomyomas along with review of cases published in literature till date.
References
M. Lin, Hanai J. Atypical lipoleiomyoma of the uterus. Acta Pathologica Japonica. 1991;41(2):164-9.
Willen R, Gad A, Willen H. Lipomatous lesions of the uterus. Virchows Arch A Pathol Anat Histopathol. 1978;377:351-61.
Akbulut M, Gundogan M, Yorukoglu A. Clinical and Pathological Features of Lipoleiomyoma of the Uterine Corpus: A Review of 76 Cases. Balkan Med. J. 2014;31(3): 224-9.
Wang X, Kumar D, Seidman JD. Uterine lipoleiomyomas: A clinicopatho- logic study of 50 cases. Int J Gynecol Pathol. 2006;25:239-42.
Hu J, Surti U, Tobon H. Cytogenetic analysis of a uterine lipoleiomyoma. Cancer Genet Cytogenet. 1992;62:200-2.
Bajaj P, Kumar G, Agarwal K. Lipoleiomyoma of broad ligament: a case report. Indian J Pathol Microbiol. 2000;43(4):457-8.
Karaman E, Cim N, Bulut G, Elci G, Andic E, Tekin M, et al. A Case of Giant Uterine Lipoleiomyoma Simulating Malignancy. Case Reports in Obstetrics and Gynecology. 2015;4.
Terda T. Giant subserosal lipoleiomyoma of the uterine cervix and corpus: A report of 2 cases. Appl Immunohistochem Mol Morphol. 2015;23(2):1-3.
Fukunaga, Masaharu. Benign “Metastasizing” Lipoleiomyoma of the Uterus. International Journal of Gynecological Pathology. 2003;22(2):202-4.
McDonald AG, Dal Cin P, Ganguly A, Campbell S, Imai Y, Rosenberg AE, et al. Liposarcoma arising in uterine lipoleiomyoma: a report of 3 cases and review of the literature. Am J Surg Pathol. 2011;35(2):221-7.