Do karyotypic abnormalities exist in young infertile women with diminished ovarian reserve?
DOI:
https://doi.org/10.18203/2320-1770.ijrcog20260546Keywords:
Diminished ovarian reserve, IVF, KaryotypeAbstract
Background: Women are endowed with a finite number of oocytes, which decrease in number and quality over time. Environmental factors, hormonal influence, iatrogenic and genetic factors impact the ovarian reserve. Diminished ovarian reserve indicating a reduction in the quantity and quality of ovarian follicular pool in women of reproductive age affects 10% women seeking fertility treatment. Objective was to find out karyotypic abnormalities in young infertile women with diminished ovarian reserve.
Methods: This retrospective study was carried out over a period of one year at the Assisted Reproductive Technology Centre of a tertiary care public sector hospital. Medical records including the infertility data of 784 couples who underwent In vitro fertilization cycle during the study period was analysed. A total of 104 women with diminished ovarian reserve as evidenced by anti-Mullerian hormone (AMH) value less than 1.1 ng/ml were included in the study.
Results: Out of 104 women with DOR, only 5 women (5 %) had slight variation in karyotype like 46XX 1qh+, 46XX 15ps+, 46XX 16qh+ which are normal polymorphic variations seen in general population. Remaining 99 (95%) women had normal female karyotype (46 XX).
Conclusions: Women with diminished ovarian reserve mostly have a normal female karyotype.
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