Bilateral incidental benign Brenner’s tumors with unilateral mucinous cystadenoma of ovary – a rare case report

Sonal T. Raut; Meera T. P.

doi:10.18203/2320-1770.ijrcog20260207

Authors

Sonal T. Raut Department of Histopathology, Manipal TRUtest Laboratory, Andheri, Mumbai, Maharashtra, India
Meera T. P. Department of Histopathology, Manipal TRUtest Laboratory, Andheri, Mumbai, Maharashtra, India

DOI:

https://doi.org/10.18203/2320-1770.ijrcog20260207

Keywords:

Brenner tumor, Mucinous cystadenoma, Adenomyoma

Abstract

Brenner tumors are unilateral and in 5-7% of cases the tumors are bilateral. These tumors are usually identified incidentally during imaging studies or surgery in post-menopausal women. Histologically, BTs are characterized by well-circumscribed nests of transitional epithelium surrounded by a fibromatous background. Brenner tumors are known to coexist with mucinous tumors of ovary. We have presented a rare case in 43-year-old pre-menopausal women presented with heavy bleeding reported as bilateral incidental Brenner’s tumor associated with unilateral mucinous cystadenoma along with other pathologies like benign endometrial polyp, adenomyoma and paratubal cyst. It highlights the awareness for extensive sampling of bilateral ovaries because of the common association with mucinous cystadenomas.

Metrics

Metrics Loading ...

References

Zheng R, Heller DS. Borderline Brenner Tumor: A Review of the Literature. Arch Pathol Lab Med. 2019;143(10):1278-80. DOI: https://doi.org/10.5858/arpa.2018-0285-RS

Borah T, Mahanta RK, Bora BD, Saikia S. Brenner tumor of ovary: An incidental finding. J Mid Life Health. 2011;2(1):40-1. DOI: https://doi.org/10.4103/0976-7800.83273

Lang SM, Mills AM, Cantrell LA. Malignant Brenner tumor of the ovary: Review and case report. Gynecol Oncol Rep. 2017;22:26-31. DOI: https://doi.org/10.1016/j.gore.2017.07.001

Mittal N, Das B, Manuja S, Gupta R. Bilateral Brenner tumor of ovary with associated unilateral mucinous cystadenoma: a case report. Int J Reprod Contracept Obstet Gynecol. 2019;8(5):2122-4. DOI: https://doi.org/10.18203/2320-1770.ijrcog20191981

Katke RD, Acharya S. Huge Brenner’s tumour of ovary (6.2kg) in a postmenopausal female - a rare case report and review of literature. J Gynecol Women’s Health. 2017;2(2): 555583. DOI: https://doi.org/10.19080/JGWH.2017.02.555583

Kotsopoulos IC, Xirou PA, Deligiannis DA, Tsapanos VS. Coexistence of three benign and a borderline tumor in the ovaries of a 52-year-old woman. Eur J Gynaecol Oncol. 2013;34(2):186-8.

Seidman JD, Khedmati F. Exploring the histogenesis of ovarian mucinous and transitional cell (Brenner) neoplasms and their relationship with Walthard cell nests: A study of 120 tumors. Arch Pathol Lab Med. 2008;132(11):1753-60. DOI: https://doi.org/10.5858/132.11.1753

Pschera H, Wikström B. Extraovarian Brenner tumor coexisting with serous cystadenoma. Case report. Gynecol Obstet Invest. 1991;31(3):185-7. DOI: https://doi.org/10.1159/000293153

Ehrlich CE, Roth LM. The Brenner tumor. A clinicopathologic study of 57 cases. Cancer. 1971;27(2):332-42. DOI: https://doi.org/10.1002/1097-0142(197102)27:2<332::AID-CNCR2820270213>3.0.CO;2-L

Alloush F, Bahmad HF, Lutz B, Poppiti R, Recine M, Alghamdi S, et al. Brenner Tumor of the Ovary: A 10-Year Single Institution Experience and Comprehensive Review of the Literature. Med Sci. 2023;11(1):18. DOI: https://doi.org/10.3390/medsci11010018

Jodha BS, Garg R. Brenner tumor of ovary: an incidental finding: a case report. Int J Reprod Contracept Obstet Gynecol. 2017;6(3):1132-5. DOI: https://doi.org/10.18203/2320-1770.ijrcog20170600

Pradhan P, Mohanty L, Pradhan D, Pujari S, Kar A. Benign brenner tumor of ovary with mucinous cystadenoma: A case report. Asian J Pharm Hea Sci. 2017;7(1):1643-6.

Wang Y, Wu RC, Shwartz LE, Haley L, Lin MT, Shih Ie M, et al. Clonality analysis of combined Brenner and mucinous tumours of the ovary reveals their monoclonal origin. J Pathol. 2015;237(2):146-51. DOI: https://doi.org/10.1002/path.4572

Montoriol PF, Hordonneau C, Boudinaud C, Molnar I, Abrial C, Kossai M. Benign Brenner tumour of the ovary: CT and MRI features. Clin Radiol. 2021;76(8):593-8. DOI: https://doi.org/10.1016/j.crad.2021.03.018

Sharma M, Khangar B, Mallya V, Khurana N, Gupta S. Coexisting Brenner Tumor and Endometrial Carcinoma. J MidLife Health. 2017;8(2):89-91. DOI: https://doi.org/10.4103/jmh.JMH_3_17