Management of iron deficiency anemia in pregnancy: a cross-sectional survey on iron formulations and taurine perception
DOI:
https://doi.org/10.18203/2320-1770.ijrcog20260882Keywords:
Hemoglobin, Ferrous ascorbate, Taurine, Iron deficiency anemiaAbstract
Background: Iron deficiency anemia (IDA) is a widespread health concern with multiple treatment options, yet obstetrician gynecologist preferences and clinical outcomes vary considerably. Taurine is gaining attention as a potential adjunct due to its role in erythropoiesis and antioxidant effects.
Methods: Cross sectional survey was conducted among 197 practicing obstetricians and gynecologists in India. A structured 9 item questionnaire assessed iron salt preferences, side effect experiences, perceptions of tablet size and patient compliance, and views on prescribing taurine containing iron supplements. Data were analyzed using descriptive statistics.
Results: Ferrous ascorbate was the preferred iron salt for 98.47% of obstetrician gynecologist, with 84.77% reporting minimal side effects. Tablet size was deemed important for compliance by 97.46% of respondents. A total of 91.87% favored prescribing taurine enriched formulations for fetal wellbeing, and 91.37% had previously prescribed R. B. Tone Rapid. Moreover, after 8 weeks of ferrous ascorbate therapy in IDA, a 25% rise in hemoglobin from baseline was the most commonly expected outcome (57.86%), followed by 50% (26.40%) and 40% (15.73%). R. B. Tone Rapid was preferred in cases of IDA (81.21%), fetal growth restriction (26.9%), and maternal obesity (28.42%). Additionally, majority of Obstetricians and Gynecologists (63.96%) recommended organizing a hemoglobin detection camp at their clinic.
Conclusions: Obstetrician gynecologist demonstrated a strong preference for ferrous ascorbate and expressed confidence in taurine containing iron therapies. The findings support a shift toward better tolerated, functionally enhanced supplements in pregnancy related IDA. Further research is needed to validate these perceptions and inform treatment guidelines.
References
Raut AK, Hiwale KM. Iron Deficiency Anemia in Pregnancy. Cureus. 2022;14(9):e28918. DOI: https://doi.org/10.7759/cureus.28918
Natekar P, Deshmukh C, Limaye D, Ramanathan V, Pawar A. A micro review of a nutritional public health challenge: iron deficiency anemia in India. Clin Epidemiol Global Health. 2022;14:100992. DOI: https://doi.org/10.1016/j.cegh.2022.100992
Georgieff MK. Iron deficiency in pregnancy. Am J Obstet Gynecol. 2020;223(4):516-24. DOI: https://doi.org/10.1016/j.ajog.2020.03.006
Tandon R, Jain A, Malhotra P. Management of Iron Deficiency Anemia in Pregnancy in India. Indian J Hematol Blood Transfus. 2018;34(2):204-15.
Tandon R, Jain A, Malhotra P. Management of iron deficiency anemia in pregnancy in India. Indian J Hematol Blood Transfusion. 2018;34:204-15. DOI: https://doi.org/10.1007/s12288-018-0949-6
Pantopoulos K. Oral iron supplementation: new formulations, old questions. Haematologica. 2024;109(9):2790-801. DOI: https://doi.org/10.3324/haematol.2024.284967
Hussain T, Tan B, Murtaza G, Metwally E, Yang H, Kalhoro MS, et al. Role of Dietary Amino Acids and Nutrient Sensing System in Pregnancy Associated Disorders. Front Pharmacol. 2020;11:586979. DOI: https://doi.org/10.3389/fphar.2020.586979
Lourenço R, Camilo ME. Taurine: a conditionally essential amino acid in humans? An overview in health and disease. Nutr Hosp. 2002;17(6):262-70.
Sirdah MM, El-Agouza IM, Abu Shahla AN. Possible ameliorative effect of taurine in the treatment of iron-deficiency anaemia in female university students of Gaza, Palestine. Eur J Haematol. 2002;69(4):236-42. DOI: https://doi.org/10.1034/j.1600-0609.2002.02722.x
Bertolone L, Roy MK, Hay AM, Morrison EJ, Stefanoni D, Fu X, et al. Impact of taurine on red blood cell metabolism and implications for blood storage. Transfusion. 2020;60(6):1212-26. DOI: https://doi.org/10.1111/trf.15810
Srivastava R, Kant S, Singh AK, Saxena R, Yadav K, Pandav CS. Effect of iron and folic acid tablet versus capsule formulation on treatment compliance and iron status among pregnant women: A randomized controlled trial. J Family Med Prim Care. 2019;8(2):378-84. DOI: https://doi.org/10.4103/jfmpc.jfmpc_339_18
Patil AS, Sheng J, Dotters-Katz SK, Schmoll MS, Onslow M, Pierson RC. Fundamentals of Clinical Pharmacology With Application for Pregnant Women. J Midwifery Womens Health. 2017;62(3):298-307. DOI: https://doi.org/10.1111/jmwh.12621
Manipriyanka K, Naidu RK. Advances in Drug Formulation Technology: Enhancing Bioavailability and Patient Compliance. J Advanced Zool. 2023;44. DOI: https://doi.org/10.17762/jaz.v44iS-5.1719
Govindaraju SLM, Yalamanchili P, Kandipudi KLP, Vadlamani S. Comparison of the effectiveness of ferrous ascorbate with ferrous sulphate in improving haemoglobin percentage among ante-natal mothers in rural field practice area of a medical college. J Family Med Prim Care. 2024;13(10):4225-4230. DOI: https://doi.org/10.4103/jfmpc.jfmpc_201_24
Ebea-Ugwuanyi PO, Vidyasagar S, Connor JR, Frazer DM, Knutson MD, Collins JF. Oral iron therapy: Current concepts and future prospects for improving efficacy and outcomes. Br J Haematol. 2024;204(3):759-73. DOI: https://doi.org/10.1111/bjh.19268
Chavan S, Rana P, Tripathi R, Tekur U. Comparison of efficacy & safety of iron polymaltose complex & ferrous ascorbate with ferrous sulphate in pregnant women with iron-deficiency anaemia. Indian J Med Res. 2021;154(1):78-84. DOI: https://doi.org/10.4103/ijmr.IJMR_1753_18
Kardas P, Lewek P, Matyjaszczyk M. Determinants of patient adherence: a review of systematic reviews. Front Pharmacol. 2013;4:91. DOI: https://doi.org/10.3389/fphar.2013.00091
Ingersoll KS, Cohen J. The impact of medication regimen factors on adherence to chronic treatment: a review of literature. J Behav Med. 2008;31(3):213-24. DOI: https://doi.org/10.1007/s10865-007-9147-y
Tochitani S. Functions of Maternally-Derived Taurine in Fetal and Neonatal Brain Development. Adv Exp Med Biol. 2017;975 Pt 1:17-25. DOI: https://doi.org/10.1007/978-94-024-1079-2_2
Tochitani S. Taurine: A Maternally Derived Nutrient Linking Mother and Offspring. Metabolites. 2022;12(3):228. DOI: https://doi.org/10.3390/metabo12030228
Malhotra N, Kriplani A, Pal B, Bhat V, Swami O. Ferrous ascorbate: Current clinical place of therapy in the management of iron deficiency anemia. J South Asian Federation Obstet Gynaecol. 2021;13(3):104. DOI: https://doi.org/10.5005/jp-journals-10006-1896
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