Efficacy and safety of Y-spur in the treatment of male infertility disorders: an open-label clinical endpoint study
DOI:
https://doi.org/10.18203/2320-1770.ijrcog20260883Keywords:
Idiopathic male infertility, Infertility disorders, Oligospermia, Sperm morphology, Y-SpurAbstract
Background: Idiopathic male infertility has a complex etiology that includes oxidative stress, hormonal dysregulation, genetics, lifestyle choices, and environmental pollutants that can affect spermatogenesis and lower the quality of sperm. A polyherbal formulation, Y-Spur Capsule contains various herbs that support reproductive health through different methods, improve semen quality, lowers oxidative stress, and increase sperm count, motility, morphology, and testosterone levels.
Methods: 30 males aged 18-45 years, diagnosed with idiopathic male infertility were enrolled in the study and followed for 9 months.
Results: Statistically significant and sustained improvements were observed over a period of 9 months compared to their baseline values in a. semen volume (1.85±0.48 to 2.11±0.51), b. sperm concentration (11.6±1.96 to 17.7±2.37), c. total sperm count (14.4±3.06 to 22.93±2.32), d. total motile sperm (14.1±2.92 to 50.13±6.27), e. normal sperm morphology (2.67±0.48 to 11.47±1.87) (p=0.0001).
Conclusions: The progressive improvement in sperm morphology and motility further supported the overall enhancement of sperm quality and reproductive potential and the safety evaluations confirmed that Y-Spur was well tolerated. In addition, Y-spur was well tolerated among the subjects and was considered safe when consumed over a period of 9 months.
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