Fetomaternal outcomes in pregnancies complicated by thrombocytopenia: a retrospective study
DOI:
https://doi.org/10.18203/2320-1770.ijrcog20261612Keywords:
Thrombocytopenia, Pregnancy, Gestational thrombocytopenia, HELLP syndrome, Maternal outcome, Neonatal outcomeAbstract
Background: Thrombocytopenia is defined as a platelet count below 1.5 lakh/mm3. After anaemia, it is the second most common haematological disorder encountered during pregnancy. It affects approximately 6-15% of pregnancies, with an average incidence of around 10%.
Methods: This was a hospital-based retrospective observational study conducted in the Department of Obstetrics and Gynaecology at C. U. Shah Medical College and Hospital from 1 January 2024 to 31 August 2024. A total of 75 pregnant women with thrombocytopenia out of 700 delivered cases during the study period were included in the study.
Results: Out of 700 delivered cases, 75 women were found to have thrombocytopenia, while 625 had normal platelet counts. The incidence of thrombocytopenia in the present study was 10.7%. Gestational thrombocytopenia was the most common cause. Postpartum hemorrhage was the most common maternal complication, while intrauterine growth restriction and prematurity were the most common neonatal complications.
Conclusions: Thrombocytopenia in pregnancy is associated with significant maternal and neonatal morbidity. Routine antenatal platelet count monitoring facilitates early diagnosis and timely management, thereby improving fetomaternal outcomes.
Metrics
References
Sengottuvel D, Ethiraj G, Begum NA. Fetomaternal outcome of thrombocytopenia in pregnancy. Int J Reprod Contracept Obstet Gynecol. 2025;14(4):1265-71. DOI: https://doi.org/10.18203/2320-1770.ijrcog20250873
Gaba N, Gaba S. Etiology and fetomaternal outcomes of thrombocytopenia during pregnancy. Perinatology. 2020;21(2):45-9.
Padmawar A, Verma PG, Khadse G, Dhishana SR. Maternal and fetal outcome of pregnancies complicated with thrombocytopenia. Indian J Obstet Gynecol Res. 2020;7(4):540-43. DOI: https://doi.org/10.18231/j.ijogr.2020.115
Mangla A, Hamad H. Thrombocytopenia in pregnancy. In: StatPearls. Treasure Island (FL): StatPearls Publishing. 2025.
Ciobanu AM, Colibaba S, Cimpoca B, Peltecu G, Panaitescu AM. Thrombocytopenia in pregnancy. Maedica (Bucur). 2016;11(1):55-60.
Shehata N, Burrows RF, Kelton JG. Gestational thrombocytopenia. Clin Obstet Gynecol. 1999;42(2):327-34. DOI: https://doi.org/10.1097/00003081-199906000-00017
Barton JR, Sibai BM. Diagnosis and management of hemolysis, elevated liver enzymes, and low platelets syndrome. Clin Perinatol. 2004;31:807-vii. DOI: https://doi.org/10.1016/j.clp.2004.06.008
Prajapati S, Kumar NPS. A study on thrombocytopenia in pregnancy and fetomaternal outcome conducted at tertiary care center Rajkot, Gujarat. Int J Reprod Contracept Obstet Gynecol. 2023;12:1350-55. DOI: https://doi.org/10.18203/2320-1770.ijrcog20231222
Kadiyala T, John LB, Kadirvel K. Fetal and maternal outcomes of gestational thrombocytopenia: an observational study. Int J Reprod Contracept Obstet Gynecol. 2024;14(1):75-9. DOI: https://doi.org/10.18203/2320-1770.ijrcog20243927
Meshram A, Mantoo AJ, Saldanha CL, Hamid U. Fetomaternal outcome in pregnancy with gestational thrombocytopenia. J Popul Ther Clin Pharmacol. 2025;32(5):1262-8. DOI: https://doi.org/10.53555/deb8ef64
Qureshi AN, Sakina, Taqi T, Khatoon H, Ahmed I. Risk factors and fetomaternal outcome in pregnancy with thrombocytopenia. Prof Med J. 2019;26(11):1942-46. DOI: https://doi.org/10.29309/TPMJ/2019.26.11.3396
Parnas M, Sheiner E, Shoham-Vardi I, Burstein E, Yermiahu T, Levi I, et al. Moderate to severe thrombocytopenia during pregnancy. Eur J Obstet Gynecol Reprod Biol. 2006;128(1-2):163-8. DOI: https://doi.org/10.1016/j.ejogrb.2005.12.031
Gupta AK, Kumari S, Singhal A, Bahl A. Neonatal thrombocytopenia and platelet transfusion. Asian J Transfus Sci. 2012;6(2):161-4. DOI: https://doi.org/10.4103/0973-6247.98924
Modi K, Chaudhari J, Vaja D. A study of thrombocytopenia in pregnancy. Int J Reprod Contracept Obstet Gynecol. 2020;9(3):1115-9. DOI: https://doi.org/10.18203/2320-1770.ijrcog20200885
Sojitra M, Shah SR, Mehta AV, Panchal PP, Bhankhar R. Maternal outcome in pregnancy with thrombocytopenia. Int J Reprod Contracept Obstet Gynecol. 2020;9(7):2895-900. DOI: https://doi.org/10.18203/2320-1770.ijrcog20202729
Mushahary D, Marwah S, Saran A, Gupta C, Kumari K, Malik S. Feto-maternal outcome in pregnancy with thrombocytopenia and abnormal platelet indices. Cureus. 2024;16(4):e59156. DOI: https://doi.org/10.7759/cureus.59156
Downloads
Published
How to Cite
Issue
Section
