Prevalence and risk factors for placental malaria parasitemia in a tertiary hospital in north-central Nigeria
DOI:
https://doi.org/10.18203/2320-1770.ijrcog20262083Keywords:
Malaria, Nigeria, Placenta parasitaemia, Placenta malaria, Prevalence, Risk factorsAbstract
Background: Malaria in pregnancy is a major public health problem in sub-Saharan Africa. Placental malaria is recognized as a complication of malaria in pregnancy in endemic areas with adverse effects on pregnancy. Aim was to determine the prevalence and risk of placental malaria parasitaemia at delivery in Federal University Teaching Hospital, Lafia.
Methods: This was a cross-sectional study where 200 pregnant women in labour were enrolled consecutively by convenient sampling after obtaining informed consents. Maternal, cord and placental blood samples were taken for thick and thin blood film for malaria parasites after delivery. Data analysed using IBM SPSS version 23. Chi square test and regression analysis used for degree of association and independent risk factors for placental malaria determination. A p-value of less than 0.05 was considered statistically significant.
Results: The prevalences of maternal peripheral blood parasitaemia was 18.5% (37/200), placenta parasitaemia was 17,5% (35/200) and cord blood malaria parasitaemia was 13.0% (27/200). The risk factors for placental malaria parasitaemia were non-use of intermittent preventive treatment (OR=0.408, p=0.000), non-use of insecticide treated nets (OR=0.043, p=0.000) and low level of education (OR= 0.012, p=0.000).
Conclusions: The significant contributors to placental malaria parasitaemia are low level of education, non-use of intermittent preventive treatment and non-use of insecticide treated bed nets. Girl child education, use of insecticide treated nets which should be made available and free, and use of IPT as directly observed therapy should be adhered to.
References
Fehintola AO, Fehintola FO, Loto OM, Fasubaa OB, Bakare B, Ogundele O. Pregnancy and fetal outcome of placental malaria parasitemia in Ile Ife, Nigeria. Trop J Obstet Gynaecol. 2016;33(3):310-6.
WHO. World Malaria Report 2019. Geneva: World Health Organization. Available from; https://www.who.int/teams/global-malaria-programme/reports/world-malaria-report-2019. Accessed on 9 January 2026.
Zakama AK, Ozarslan N, Gaw SL. Placental Malaria. Curr Trop Med Rep. 2020;7(4):162-71.
Feleke DG, Adamu A, Gebreweld A, Tesfaye M, Demisiss W, Molla G. Asymptomatic malaria infection among pregnant women attending antenatal care in malaria endemic areas of North-Shoa, Ethiopia: a cross-sectional study. Malar J. 2020;19(1):67.
Fierer N. Embracing the Unknown: disentangling the complexities of the soil microbiome. Nat Rev Microbiol. 2017;15(10):579-90.
McDonald CR, Tran V, Kain KC. Complement activation in placental malaria. Front Microbiol. 2015;6:1460.
Pehrson C, Salanti A, Theander TG, Nielsen MA. Pre-clinical and clinical development of the first placental malaria vaccine. Expert Rev Vaccines. 2017;16(6):613-24.
Oweisi P, Omietimi J, John C, S Aigere E, Allagoa D, Kotingo E. Correlation between placental malaria parasitemia at delivery and infant birth weight in a Nigerian tertiary health centre. Niger J Med. 2018;27(2):99.
Falade CO, Tongo OO, Ogunkunle OO, Orimadegun AE. Effects of malaria in pregnancy on newborn anthropometry. J Infect Dev Ctries. 2010;4(07):448-53.
Fried M, Duffy PE. Malaria during pregnancy. Cold Spring Harb Perspect Med. 2017;7(6):a025551.
Ibanga GJ, Abasiattai AM, Bassey EA, Ukpe M, Olatunbosun OA, Ekrikpo U. Placental malaria parasitemia and pregnancy outcome among parturients in a tertiary hospital in South-South Nigeria. Asian J Med Sci. 2015;6(6):53-9.
Ezebialu IU, Eke AC, Ezeagwuna DA, Nwachukwu CE, Ifediata F, Ezebialu CU. Prevalence, pattern, and determinants of placental malaria in a population of southeastern Nigerian parturients. Int J Infect Dis; 2012;16(12):e860-5.
Bassey G, Nyengidiki TK, John CT. Prevalence of placenta plasmodium parasitemia and pregnancy outcome in asymptomatic patients at delivery in a University Teaching Hospital in Nigeria. Niger J Clin Pract. 2015;18(1):27-32.
Briggs J, Ategeka J, Kajubi R, Ochieng T, Kakuru A, Ssemanda C, at al. Impact of microscopic and submicroscopic parasitemia during pregnancy on placental malaria in a high transmission setting in Uganda. J Infect Dis. 2019;220(3):457-66.
Mokuolu OA, Falade CO, Orogade AA, Okafor HU, Adedoyin OT, Oguonu TA et al. Malaria at parturition in Nigeria: current status and delivery outcome. Infect Dis Obstet Gynaecol. 2009;473971.
Umemmuo MU, Agboghoroma CO, Iregbu KC. The efficacy of intermittent preventive therapy in the eradication of peripheral and placental parasitemia in a malaria-endemic environment, as seen in a tertiary hospital in Abuja, Nigeria. Int J Gynecol Obstet. 2020;148(3):338-43.
Babalola AS, Idowu OA, Sam-Wobo SO, Fabusoro AE. Malaria infection at parturition in Abeokuta, Nigeria: Current status and pregnancy outcome. Malariaworld J. 2017;8:12.
Toure OA, Konan CB, Kouame VN, Gbessi EA, Soumahoro A, Bassinka I, et al. Risk factors for placental malaria and associated low birth weight in a rural high malaria transmission setting of Cote d Ivoire. Trop Parasitol. 2020;10(2):102-8.
National Antimalaria Treatment Guidelines. Publication of the Federal Ministry of Health National Malaria and Vector Control Division, Abuja, Nigeria. 2005.
Yeboah DF, Afoakwah R, Nwaefuna EK, Verner O, Boampong JN. Quality of sulfadoxine-pyrimethamine given as antimalaria prophylaxis in pregnant women in selected health facilities in central region of Ghana. J Parasitol Res. 2016;2016:9231946.
Falade CO, Yusuf BO, Fadero FF, Mokuolu OA, Hammer DH, Salako LA. Intermittent prevention with sulphadoxine- pyrimethamine in Ibadan, South-Western Nigeria. Malar J. 2007;6:88.
Olumese P. Malaria control: WHO Technical Updates. Geneva Switzerland: World Health Organization; 2014.
Federal Ministry of Health (FMoH). National Guidelines and Strategies for Malaria. Prevention and Control During Pregnancy. 2nd edn. Federal Ministry of Health. Nigeria; 2014.
Sule-Odu AO, Ogunledun A, Olatunji AO. Impact of asymptomatic maternal malaria parasitemia at parturition on perinatal outcome. J Obstet Gynecol. 20l2;22(1):25-8.
Bako BG, Audu BM, Geidam AD, Kullima AA, Ashiru GM, Malah MB, et al. Prevalence, risk factors and effects of placental malaria in the UMTH, Maiduguri, North-eastern, Nigeria: a cross-sectional study. J Obstet Gynecol. 2009;29(4):307-10.
Abiti AH, Adam I, Ghouth AS. Placental malaria, anaemia and low birthweight in Yemen. Transact Royal Soc Trop Med Hyg. 2010;104(3):191-4.
Ogbu GI, Aimakhu CO, Anzaku SA, Ngwan S, Ogbu DA. Prevalence of malaria parasitemia among asymptomatic women at booking visit in a tertiary hospital, North- central Nigeria. J Reprod Biol Health. 2015;3(1):2054-841.
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