Spontaneous regression of uterine fibroids in a perimenopausal woman: a case report on alternative approaches to symptom management

Abstract

Uterine fibroids are the most common benign tumours in females, with the highest incidence in women aged 35 to 45 years. Although conventional treatments typically involve hormonal therapy, myomectomy, or hysterectomy, some patients seek non-surgical alternatives due to concerns about invasiveness, fertility preservation, or personal preferences. This case is notable for its use of an indigenous remedy, Lachesis, traditionally derived from snake venom, as a complementary treatment in managing symptomatic uterine fibroids. The novelty lies in the documented improvement following this alternative therapy, providing a potential avenue for further exploration in non-surgical management. A 40-year-old female presented with a three-year history of irregular, heavy, and painful menstrual cycles. Imaging studies revealed multiple uterine fibroids involving the body and posterior wall of the uterus, with subserosal extension. Despite multiple surgical recommendations, the patient declined operative intervention and instead pursued an indigenous treatment plan. She initiated therapy with Lachesis, an indigenous remedy known for its use in hormonal and circulatory disorders, after ensuring compatibility with tranexamic acid, which was prescribed for bleeding control. Over time, she reported progressive symptom relief, including reduced menstrual pain and improved cycle regularity. Serial follow-up ultrasounds showed a decrease in fibroid size, correlating with clinical improvement. Her medical history was notable for left oophorectomy in 2015 and a family history of fibroids, with both her mother and sister affected, the former undergoing hysterectomy and the latter opting for conservative management. This case suggests the potential of an indigenous, non-surgical approach in managing uterine fibroids, particularly in patients who refuse surgery. Although the precise mechanism of action of Lachesis in fibroid regression remains uncertain, its association with symptomatic and radiological improvement indicates a possible therapeutic role. These findings support the need for more rigorous investigation into alternative and complementary therapies. As patient demand grows for non-invasive treatment options, such cases underscore the importance of further clinical studies to evaluate efficacy, safety, and integration of traditional remedies into modern gynaecological care.