Collision tumor of ovary: an uncommon entity

Aprajita Garg; Pooja Sharma

doi:10.18203/2320-1770.ijrcog20262589

Authors

Aprajita Garg Department of Pathology, Dr. Lal Path Labs Limited, Chandigarh, India
Pooja Sharma Department of Pathology, Dr. Lal Path Labs Limited, Chandigarh, India

DOI:

https://doi.org/10.18203/2320-1770.ijrcog20262589

Keywords:

Collision tumor, Ovary, Serous cystadenoma, Mature cystic teratoma

Abstract

Collision tumors are a rare group of neoplasms characterized by coexistence of histologically distant type of tumors in the same organ without any evidence of histological intermixing. We present a case of 35 years old female presenting with irregular menstrual cycle and was found to have collision of tumor of ovary composed of serous cystadenoma and mature cystic teratoma on histopathological evaluation. No histological admixture was found between the two lesions. These tumors are exceptionally uncommon entities and may present with diagnostic dilemma due to their complex morphology. This case, thus, highlights the importance of histopathological evaluation in diagnosing this entity. Awareness of this rare entity is also essential as early recognition influences prognosis, therapeutic decisions and patient follow up.

References

Sharan JP, Dorothy LF, Nayak SR, Arun R, Deepika B. Collision tumor of ovary: A rare entity. Int J Innov Res Dev. 2014;3:424-7.

Priyanka B, Pranab D. Bilateral Serous adenocarcinoma of Ovary coexisting with mature cystic teratoma- Case report and review of literature. Ann Pathol Lab Med. 2015;2:71-4.

Pepe F, Panella M, Pepe G, Panella P, Pennisi F, Arikian S. Dermoid cysts of the ovary. Eur J Gynaecol Oncol. 1986;7(3):186-91.

Singh AK, Singh M. Collision tumours of ovary: a very rare case series. J Clin Diagn Res. 2014;8(11):FD14-6.

Ravikanth R. A rare case of collision tumor: Massive mucinous cystadenoma and benign mature cystic teratoma arising in the same ovary. CHRISMED J Health Res. 2017;4:201-3.

Feeley KM, Wells M. Precursor lesions of ovarian epithelial malignancy. Histopathology. 2001;38(2):87-95.

Cabibi D, Martorana A, Cappello F, Barresi E, Di Gangi C, Rodolico V. Carcinosarcoma of monoclonal origin arising in a dermoid cyst of ovary: a case report. BMC Cancer. 2006;6:47.

Prat J, Scully RE. Sarcomas in ovarian mucinous tumors: a report of two cases. Cancer 1979;44:1327-31.

Allen C, Stephens M, Williams J. Combined high grade sarcoma and serous ovarian neoplasm. J Clin Pathol. 1992;45(3):263-4.

Seo EJ, Kwon HJ, Shim SI. Ovarian serous cystadenoma associated with Sertoli-Leydig cell tumor--a case report. J Korean Med Sci. 1996;11(1):84-7.

Triratanachat S, Niruthisard S, Trivijitsilp P. Granulosa cell tumor and ovarian hepatoid carcinoma as a collision tumor. Chula Med J. 2004;48:101-9.

Schoolmeester JK, Keeney GL. Collision tumour of the ovary: adult granulose cell tumour and endometroid carcinoma. Int J Gynecol Pathol. 2012;31:538-40.

Nirenberg A, Ostör AG, Quinn MA. Collision tumor: serous adenocarcinoma and steroid cell tumor of the ovary. Pathology. 1992;24(2):60-2.

Cohen A, Geller SA, Horowitz I, Toth LS, Werther JL. Experimental models for gastric leiomyosarcoma. The effects of N-methyl-N'-nitro-N-nitrosoguanidine in combination with stress, aspirin, or sodium taurocholate. Cancer. 1984;53(5):1088-92.

Brahmania M, Kanthan CS, Kanthan R. Collision tumor of the colon--colonic adenocarcinoma and ovarian granulosa cell tumor. World J Surg Oncol. 2007;5:118.

Louis DN, Ramesh V, Gusella JF. Neuropathology and molecular genetics of neurofibromatosis 2 and related tumors. Brain Pathol. 1995;5(2):163-72.

Lewin K. Carcinoid tumors and the mixed (composite) glandular-endocrine cell carcinomas. Am J Surg Pathol. 1987;11:71-86.