Correlation of prolactin and thyroid disorders in infertile women

Authors

  • Priyanka Sharma Department of Obstetrics and Gynecology, IGMC, Shimla, Himachal Pradesh, India
  • Anita Pal Department of Obstetrics and Gynecology, IGMC, Shimla, Himachal Pradesh, India
  • Rajeev Sood Department of Obstetrics and Gynecology, IGMC, Shimla, Himachal Pradesh, India
  • Saroj Jaswal Department of Biochemistry, IGMC, Shimla, Himachal Pradesh, India
  • Suman Thakur Department of Obstetrics and Gynecology, IGMC, Shimla, Himachal Pradesh, India
  • Anupam Sharma Department of Obstetrics and Gynecology, IGMC, Shimla, Himachal Pradesh, India

DOI:

https://doi.org/10.18203/2320-1770.ijrcog20170400

Keywords:

Galactorrhoea, Hypothyroidism, Hyperprolactinaemia, Infertility, Oligomenorrhoea

Abstract

Background: The objective of the study was to review the impact of thyroid status on the fertility and to study the prevalence of hyperprolactinaemia in infertility.

Methods: A total of 150 subjects were divided into 3 groups: 50 primary infertility, 50 secondary infertility and 50 controls. The incidence of hyperprolactinaemia and thyroid disorders was studied in all the three groups.

Results: The incidence of hyperprolactinaemia was 41% in all infertile subjects (60% with primary and 22% in secondary infertility) and 6% in controls. The incidence of hypothyroidism was 17% in infertility (18% in primary and 16% in secondary infertility) and 8% in controls.

Conclusions: In this study there is a positive correlation between increased prolactin levels and hypothyroidism and such patients’ exhibit ovulatory failure. All patients with infertility should undergo prolactin levels and thyroid profile.

References

Mascarenhas MN, Flaxman SR, Boerma T, Vanderpoel S, Stevens GA. National, Regional, and Global Trends in Infertility Prevalence Since 1990: A systematic analysis of 277 Health Surveys. Available from: http://www.plosmedicine.org/article/info%3Adoi%2FIO.137%2Fjournal.pmed.100135.

Avasthi K, Kaur J, Gupta S, Narang P A. Hyperprolactinemia and its correlation with hypothyroidism in infertile women. J Obstet Gynecol India. 2006;56(1):68-71.

Rijal B, Shrestha R, Jha B. Association of thyroid dysfunction among infertile women visiting infertility center of Om Hospital, Kathmandu, Nepal. Nepal Med Coll J. 2011;13(4): 247-49.

Agrawal M, Samal S, Hariharan C, Agrawal S. Prevalence of hyperprolactinemia in infertile cases and its correlation with TSH in a rural set up hospital. Intern J Reprod Contracep Obstet Gynaecol. 2013;2(4):626-630.

Zargar AH, Laway BA, Masoodi SR, Bhat MH, Wani AI, Bashir MI, et al. Clinical and Etiological Profile of Hyperprolactinemia-Data from a Tertiary Care Centre. JAPI. 2005;53:288-90.

Emokpae MA, Osadolor HB,Omole OA. Sub-clinical hypothyroidism in infertile Nigerian women with Hyperprolactinaemia. Nig J Physiol Sci. 2011;26:035-8.

Akhter N, Hassan S. Sub-clinical hypothyroidism and hyperprolactinaemia in infertile women: Bangladesh perspective after universal salt iodination. Intern J Endocrino. 2008;5(1).

Goswami B, Patel S, Chatterjee M, Koner BC, Saxena A. Correlation of Prolactin and Thyroid Hormone Concentration with Menstrual Patterns in Infertile Women. J Reprod Infertil. 2009;10(3):207-12.

Mohan K, Sultana M. Follicle Stimulating Hormone, Luteinizing Hormone and Prolactin Levels in Infertile Women in Northern Chennai,Tamil Nadu. J Biosci Res. 2010;1(4):279-84.

Sharma P, Suvarna P, Tangri N. Female infertility and its correlation with serum Prolactin and TSH Concentration- An unmatched case control study.J Pharma Biomed Sci. 2013;30(30):902-7.

Mishra R, Baveja R, Gupta V, Gupta P. Prolactin Level in Infertility with Menstrual Irregularities. J Obstet Gynecol India. 2002;52(6):40-3.

Pereira-Lima JF, Leaes CG, Neto FM, Barbosa MV, da Silva ALM, Oliveira MdC. Hyperprolactinaemia and body weight: prevalence of obesity and overweight in patients with hyperprolactinaemia. Res J Endocrinol Metab. 2013;1:2.

Verma I, Sood R, Juneja S, Kaur S. Prevalence of hypothyroidism in infertile women and evaluation of response of treatment of hypothyroidism on infertility. Intern J App Basic Med Res. 2012;2(1):17-9.

Alnaksh AH, Al-Tae NK. Polycystic ovarian syndrome: the correlation between the LH/FSH ratio and disease manifestations. Middle East Fert Soc J. 2007;12(1):35-40.

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Published

2017-01-31

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Original Research Articles