Distinct gestational trophoblastic neoplasia - different entities, specific management

Pedro Brandão; Juliana Silva-Rocha; Ana Rita Pinto; Fernanda Costa

doi:10.18203/2320-1770.ijrcog20170418

Authors

Pedro Brandão Department of Obstetrics and Gynaecology, Centro Hospitalar Tâmega e Sousa Av. Hospital Padre Américo 210, 4564-007 Penafiel, Porto, Portugal
Juliana Silva-Rocha Department of Obstetrics and Gynaecology, Centro Hospitalar Tâmega e Sousa Av. Hospital Padre Américo 210, 4564-007 Penafiel, Porto, Portugal
Ana Rita Pinto Department of Obstetrics and Gynaecology, Centro Hospitalar Tâmega e Sousa Av. Hospital Padre Américo 210, 4564-007 Penafiel, Porto, Portugal
Fernanda Costa Department of Obstetrics and Gynaecology, Centro Hospitalar Tâmega e Sousa Av. Hospital Padre Américo 210, 4564-007 Penafiel, Porto, Portugal

DOI:

https://doi.org/10.18203/2320-1770.ijrcog20170418

Keywords:

Gestational trophoblastic disease, Gestational trophoblastic neoplasia, Hydatidiform mole, Placental-site, Trophoblastic tumour

Abstract

Gestational trophoblastic diseases are abnormalities of the trophoblastic tissue development. They have Β-hCG as tumour marker, similar clinical manifestations but different pathological features, management and prognosis. Gestational trophoblastic neoplasia includes all forms of gestational trophoblastic disease that are invasive and/or metastasize and correspond to 10% of this group of diseases. The authors performed a retrospective review of all patients referred to our department between 1st January 2011 and 30^th June 2016. Presenting symptoms, Β-hCG levels, obstetric and personal history and microscopic features were reviewed. 4 cases were identified - 2 invasive complete and 1 partial hydatidiform moles and 1 placental site trophoblastic tumour. Management and follow-up were individualized. Neither persistence nor recurrences were diagnosed after primary treatment. These case series highlights the importance of an accurate diagnosis and a long-term follow-up considering the risk of persistency or malignancy, as gestational trophoblastic neoplasia usually have good response to the adequate therapy.

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