Published: 2017-01-31

A case of ovarian hyperstimulation syndrome with spontaneous hemoperitoneum

Prasad R. Lele, Manoj Kumar Tangri


We report a case of complicated severe OHSS that developed spontaneous hemoperitoneum. This was a potentially fatal complication of pharmacological stimulation of ovary in assisted reproduction. Here the life was saved, oophorectomy was prevented and fertility preserved by timely diagnosis and conservative surgery.


Haemoperitoneum, OHSS

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Devroey P, Adriaensen P. OHSS Free Clinic Facts Views Vis Obgyn. 2011;3(1):43-5.

Humaidan P, Quatartarolo J, Papanikolaou EG. Preventing ovarian hyperstimulation syndrome: guidance for the clinician. Fertil Steril. 2010;94(2):389-400.

Papanikolaou EG, Pozzobon C, Kolibianakis EM, et al. Incidence and prediction of ovarian hyperstimulation syndrome in women undergoing gonadotropin-releasing hormone antagonist in vitro fertilization cycles. Fertil Steril. 2006;85:112-20.

Al Omari W, Ghazal-Aswad S, Sidky IH, Al Bassam MK. Ovarian salvage in bilaterally complicated severe ovarian hyperstimulation syndrome. Fertil Steril. 2011;96(2):e77-9.

Fiedler K, Ezcurra D. Predicting and preventing ovarian hyperstimulation syndrome (OHSS): the need for individualized not standardized treatment. Reprod Biol Endocrinol. 2012;10:32.

Krishnan S, Kaur H, Bali J, Rao K. Ovarian torsion in infertility management - Missing the diagnosis means losing the ovary: A high price to pay J Hum Reprod Sci. 2011;4(1):39-42.

Maxwell, K.N., Cholst, I.N., Rosenwaks, Z.The incidence of both serious and minor complications in young women undergoing oocyte donation. Fertil Steril. 2008;90:2165-71.

Gunabushanam G, Mandal K, Lal S. Hemoperitoneum from ruptured cyst in a hyperstimulated ovary: a sonographic mimic of ovarian hyperstimulation syndrome. J Clin Ultrasound. 2007;35(5):281-3.

Hertzberg, B.S., Kliewer, M.A., and Paulson, E.K. Ovarian cysts rupture causing hemoperitoneum: imaging features and the potential for misdiagnosis. Abdom Imaging. 1999;24:304-8.

Naredi N, Talwar P, Sandeep K. VEGF antagonist for the prevention of ovarian hyperstimulation syndrome: Current status. Med J Armed Forces India. 2014;70(1):58-63.