A case of extra hepatic portal vein obstruction in pregnancy with superimposed pre-eclampsia

Authors

  • Bindu Nambisan Department of Obstetrics and Gynaecology, Medical College, Trivandrum, Kerala, India
  • Sreekumary Radha Department of Obstetrics and Gynaecology, Medical College, Trivandrum, Kerala, India
  • Mayadevi Brahmanandan Department of Obstetrics and Gynaecology, Medical College, Trivandrum, Kerala, India
  • Libu Gnanaseelan Kanakamma Department of Obstetrics and Gynaecology, Medical College, Trivandrum, Kerala, India

DOI:

https://doi.org/10.18203/2320-1770.ijrcog20163015

Keywords:

EHPVO, Preeclampsia, EVL

Abstract

Extra hepatic portal vein obstruction in pregnancy poses a clinical challenge by itself. We present here a case of a 19 year old primigravida with EHPVO who developed superimposed preeclampsia. She had a successful maternal and fetal outcome in a tertiary care centre owing to the team effort involving specialists from medical gastroenterology, nephrology, anesthesiology, and neonatology apart from senior obstetrician. EHPVO is an important cause of non-cirrhotic portal hypertension in third world countries. In pregnancy, the increased blood volume and cardiac output and mesenteric vasodilatation will increase portal flow and aggravate portal hypertension in these patients. The resultant hematemesis in such patients, can compromise the perinatal outcome. Endoscopic variceal ligation (EVL) reduces the risk of variceal bleeding, and can improve the pregnancy outcome in these women. Thrombocytopenia due to splenomegaly is one of the major complications in these patients and has to be corrected before pregnancy. Platelet transfusion is required intrapartum if the count is less than 50,000/mm3 caesarean delivery is reserved only for obstetric indications.

References

de Franchis R, Baveno V. Faculty. Revising consensus in portal hypertension: report of the Baveno V consensus workshop on methodology of diagnosis and therapy in portal hypertension. J Hepatol. 2010;53(4):762-8.

Sarin SK, Sollano JD, Chawla YK, Amarapurkar D, Hamid S, Hashizume M, et al. Members of the APASL working party on portal hypertension. Consensus on extra-hepatic portal vein obstruction. Liver Int. 2006;26(5):512-9.

Aggarwal N, Sawhney H, Vasishta K, Dhiman RK, Chawla Y. Non-cirrhotic portal hypertension in pregnancy. Int J Gynaecol Obstet. 2001;72(1):1-7.

Mandal D, Dattaray C, Sarkar R, Mandal S, Choudhary A, Maity TK. Is pregnancy safe with extrahepatic portal vein obstruction? An analysis. Singapore Med J. 2012;53(10):676-80.

Dilawari JB, Chawla YK. Extra-hepatic portal venous obstruction. Gut. 1988;29(4):554-5.

Kochhar R, Kumar S, Goel RC, Sriram PV, Goenka MK, Singh K. Pregnancy and its outcome in patients with non-cirrhotic portal hypertension. Dig Dis Sci. 1999;44(7):1356-61.

López-Méndez E, Avila-Escobedo L. Pregnancy and portal hypertension a pathology view of physiologic changes. Ann Hepatol. 2006;5(3):219-23.

Sumana G, Dadhwal V, Deka D, Mittal S. Non-cirrhotic portal hypertension and pregnancy outcome. J Obstet Gynaecol Res. 2008;34(5):801-4.

Sarin SK, Lamba GS, Kumar M, Misra A, Murthy NS. Comparison of endoscopic ligation and propranolol for the primary prevention of variceal bleeding. N Engl J Med. 1999;340(13):988-93.

Meidahl Petersen K, Jimenez-Solem E, Andersen JT, Petersen M, Brødbæk K, Køber L, et al. β-Blocker treatment during pregnancy and adverse pregnancy outcomes: a nationwide population-based cohort study. BMJ Open. 2012;2(4):e001185.

Downloads

Published

2017-02-03

Issue

Section

Case Reports