Placental site trophoblastic tumor presented with unusual presentation

Rajdeep Meena, , Santosh Meena


Placental site trophoblastic tumor (PSTT) is a rarest type of gestational trophoblastic tumor. It is rising from the abnormal proliferation of intermediate trophoblastic cells with occasional multinuclear giant cells, with the potential for local invasion and metastasis. A 28 year old G4P3 woman presented with 4 months Amenorrhea, large uterine mass and plateau low level of serum human chorionic gonadotropin (hCG) which raised the possibility of PSTT. Since whole myometrium has been substituted with the large tumoral mass, hysterectomy was considered despite the young age of the patient. The patient has been in remission 12 months postoperatively without receiving any adjuvant treatment. It seems that plateau low levels of hCG in the presence of amenorrhea should prompt the possibility of PSTT.


Placental site trophoblastic tumor, Gestational trophoblastic neoplasia, Metastasis

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Kurman RJ, Scully RE, Nrris HJ. Trophoblastic pseudotumor of the uterus. An exaggerated form of syncytial endometritis, simulating a malignant tumor. Cancer. 1976;7:1214-26.

Soper JT, Mutch DG, Schink JC American College of Obstetrics and Gynecologists. Diagnosis and treatment of gestational trophoblastic disease.ACOG practice Bulletin: No. 53. Gynecol Oncol. 2004;93(3):575-85.

Hassadia A, Gillespie A, Tidy J, Everard RGNJ, Wells M, Coleman R, et al. Placental site trophoblastic tumor: Clinical features and management. Gynecol Oncol. 2005;99(3):603-7.

Sudha CP, Sahana M. Chemoresistant gestational trophoblastic neoplasia: a case report. J Clin Diagn Res. 2014;8:OD12-3.