Two interesting cases of gestational trophoblastic disease with methotrexate failure

Poonam Laul; Pinkee Saxena; Vijay K. Kadam; Urvashi Miglani

doi:10.18203/2320-1770.ijrcog20163027

Authors

Poonam Laul Department of Obstetrics and Gynecology, Deen Dayal Upadhyaya Hospital, Hari Nagar, New Delhi - 110064, India
Pinkee Saxena Department of Obstetrics and Gynecology, Deen Dayal Upadhyaya Hospital, Hari Nagar, New Delhi - 110064, India
Vijay K. Kadam Department of Obstetrics and Gynecology, Deen Dayal Upadhyaya Hospital, Hari Nagar, New Delhi - 110064, India
Urvashi Miglani Department of Obstetrics and Gynecology, Deen Dayal Upadhyaya Hospital, Hari Nagar, New Delhi - 110064, India

DOI:

https://doi.org/10.18203/2320-1770.ijrcog20163027

Keywords:

Choriocarcinoma, Uterine perforation, Methotrexate

Abstract

Gestational trophoblastic disease is group tumours that are more sensitive and respond well to a wide variety of chemotherapeutic regimes. Presented here are two interesting cases one with life threatening bleeding requiring hysterectomy and other with persistent disease post evacuation. Both being low risk were treated with single agent methotrexate, but failed to respond. They responded to alternative chemotherapy. Methotrexate resistant is seen even in low risk group.

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