Age at menarche as a predictor of diminished ovarian reserve: a new approach

Ramona Perhar, Rita Shukla, Akanksha Mishra


Background: Objective of current study was to investigate whether age at menarche is associated with Functional Ovarian Reserve (FOR) later in life.

Methods: Design: Retrospective cohort study. Setting: Gayatri Hospital, Allahabad, Uttar Pradesh, India. Patient(s): One hundred fifty one. Intervention(s): None.

Results: The mean age of the patients was 38.9 ± 4.9 years, and their mean level of AMH was 1.4 ± 2.0 ng/ml and of FSH was 10.7 ± 6.1 mIU/ml. Their current age-specific Diminished Functional Ovarian Reserve (DFOR) was statistically significantly associated with early menarche, defined as age <13 years. Logistic regression analysis affirmed the higher likelihood of early age of menarche in infertile patients with DFOR. When women with DFOR were grouped into quartiles, early menarche (<25th percentile) was associated with statistically significantly higher DFOR risk than late menarche (>75th percentile).  

Conclusions: The study demonstrates a statistically significant impact of menarche on DFOR risk later in life among infertile women. The occurrence of menarche may relate to follicular pool size and/or speed of follicle recruitment, which in turn, is predictive of occurrence of DFOR later in life. 


Anti-Mullerian hormone (AMH), follicle-stimulating hormone (FSH), Diminished functional ovarian reserve, menarche, Ovarian function

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