Comparative study of various tocolytics in preterm labour

Authors

  • Neetu Singh Department of Obstetrics and Gynaecology, GSVM Medical College, Kanpur, UP, India
  • Preeti Dubey Department of Obstetrics and Gynaecology, GSVM Medical College, Kanpur, UP, India
  • Neena Gupta Department of Obstetrics and Gynaecology, GSVM Medical College, Kanpur, UP, India
  • Seema Dwivedi Department of Obstetrics and Gynaecology, GSVM Medical College, Kanpur, UP, India
  • Rashmi Balyan Department of Obstetrics and Gynaecology, GSVM Medical College, Kanpur, UP, India
  • Ani Chandanan Department of Obstetrics and Gynaecology, GSVM Medical College, Kanpur, UP, India

Keywords:

Tocolytics, Short-term, Preterm delivery

Abstract

Background: Preterm birth is one of the major factors responsible for neonatal mortality and morbidity. In this study, we have to see the role of various tocolytics in preventing preterm labour.

Methods: The observational study was conducted on 200 patients admitted in Upper India Sugar Exchange Maternity Hospital, Kanpur.

Results: In our study calcium channel blocker were associated with statistically and clinically significantly better neonatal outcome and fewer maternal side effects than any other tocolytic. So calcium channel blocker would be preferred first line tocolytic with regard to several important outcomes.

Conclusions: Preterm birth continued to be problem for obstetrician. Administration of short term tocolytic agents can prolong pregnancy for women in pre-term labor. Prolonging pregnancy may have benefits because it allows for other proven interventions, such as antenatal corticosteroid administration to be accomplished. The reviews proven an overview currently utilize tocolytic agents and the evidence of demonstrating their efficacy for prolonging pregnancy by at least 48 hours.

References

Martin JA, Hamilton BE, Ventura SJ, Menacker F, Park MM, Sutton PD. Births: final data for 2001. National Statistics Report 2002;51(2):1-104.

Haas DM, Benjamin T, Sawyer R,Quinney SK. Short-term tocolytics for preterm delivery - current perspectives. Int J Womens Health. 2014;6:343-9.

Kramer MS, Goulet L, Lydon J, Seguin L, McNamara H, Dassa C, et al. Socio-economic disparities in preterm birth: causal pathways and mechanisms. Paediatr Perinat Epidemiol. 2001;15 Suppl 2:104-23.

King JF, Grant A, Keirse MJ,Chalmers I. Beta-mimetics in preterm labour: an overview of the randomized controlled trials. Br J Obstet Gynaecol. 1988;95(3):211-22.

Lees CC, Lojacono A, Thompson C, Danti L, Black RS, Tanzi P, et al. Glyceryl trinitrate and ritodrine in tocolysis: an international multicenter randomized study. GTN Preterm Labour Investigation Group. Obstet Gynecol. 1999;94(3):403-8.

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Published

2017-02-06

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Section

Original Research Articles