Plasma level of D-dimer accompanying different types of gynecologic surgery and effects of prophylactic subcutaneous injection of heparin calcium

Authors

  • Sakika Yanai Department of Obstetrics & Gynecology, Osaka City University Graduate School of Medicine, 1-4-3, Asahimachi-545-8585, Osaka, Japan
  • Yusuke Nakano Department of Gynecology, Izumi Municipal Hospital, 4-10-10, Huchucho, Izumi-594-0071, Osaka, Japan
  • Ken-ichi Honda Department of Obstetrics & Gynecology, Kashiwara Municipal Hospital, 1-7-9, Houzenji, Kashiwara-582-0005, Osaka, Japan
  • Tomoko Sumikura Division of Gynecology, National Cancer Center Hospital, Kashiwanoha, Kashiwa-277-8577, Chiba, Japan
  • Saori Seo Department of Obstetrics & Gynecology, Osaka City University Graduate School of Medicine, 1-4-3, Asahimachi-545-8585, Osaka, Japan
  • Yutaka Inoue Department of Obstetrics & Gynecology, Kashiwara Municipal Hospital, 1-7-9, Houzenji, Kashiwara-582-0005, Osaka, Japan
  • Naohiko Umesaki Department of Gynecology, Izumi Municipal Hospital, 4-10-10, Huchucho, Izumi-594-0071, Osaka, Japan

DOI:

https://doi.org/10.18203/2320-1770.ijrcog20150049

Keywords:

D-dimer, DPE, POD-1, Gynecologic surgery, Heparin calcium

Abstract

Background: The standard range of D-dimer level associated with each type of gynecologic surgery is required to note the occurrence of bleeding or thromboembolism.

Methods: Plasma levels of D-dimer of patients who underwent different types of gynecologic surgery were measured on the Day of Preoperative Examination (DPE) and the first postoperative day (POD-1). Patients were classified by surgery type: hysterectomy for benign diseases or cervical intraepithelial neoplasia; hysterectomy for uterine cancer; surgery for ovarian cancer; laparoscopic surgery for a benign adnexal mass; laparotomy for a benign adnexal mass; laparotomic myomectomy; cervical conization; transcervical resection of an intrauterine mass; vaginal surgery for prolapse of a pelvic organ.

Results: In each type of gynecologic surgery, plasma levels of D-dimer on POD-1 were higher than those on the DPE. Prophylactic subcutaneous injection of heparin calcium for patients who underwent surgery for endometrial cancer showed no significant difference in the plasma level of D-dimer on the sixth postoperative day (POD-6) and the plasma level of D-dimer on POD-6 was in the same level as those on POD-1.

Conclusions: Plasma levels of D-dimer on POD-1 were higher than those on the DPE in each type of gynecologic surgery. The D-dimer level remained high even on POD-6, and not changed by prophylactic subcutaneous injection of heparin calcium. 

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Published

2017-02-08

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Original Research Articles