A rare case of CNS tuberculosis with pregnancy


  • Sanjay Singh Department of Obstetrics & Gynaecology, Armed Forces Medical College, Pune-411040, Maharashtra, India
  • Tony Jose Department of Obstetrics & Gynaecology, Armed Forces Medical College, Pune-411040, Maharashtra, India
  • Puneet Saxena Department of Respiratory Medicine, Armed Forces Medical College, Pune-411040, Maharashtra, India




Tuberculosis, Central nervous system, Meningitis, Pregnancy, ATT


Whereas pelvic tuberculosis leading to infertility is quite common in female population of developing countries, Central Nervous System (CNS) tuberculosis (TB) with pregnancy is a rare entity. Most of the information on this subject is based on sporadic case reports only. Most of the earlier reports suggest very high adverse outcome of CNS Tuberculosis in pregnancy. We are presenting a case of CNS Tuberculosis which was diagnosed timely and managed appropriately in our institute with a favourable outcome, thus highlighting the importance of early diagnosis and treatment.


Parikh FR, Naik N, Nadkarni SG, Soonawala SB, Kamat SA, Parikh RM. Genital tuberculosis is a major pelvic factor causing infertility in Indian women. Fertil Steril. 1997;67:497.

D’Cruz IA, Dandeker AC. Tuberculous meningitis in pregnant and puerperal women. Obstet Gynecol. 1968;31:775-9.

Fallon RJ, Kennedy DH. Treatment and prognosis in tuberculous meningitis. J Infect (Suppl). 1981;3(1):39-41.

John CP. Ktngdom, Dermot H. Kennedy. Tuberculous meningitis in pregnancy. Br J Obstet Gynaecol. 1989 Feb;96:233-5.

Prevost MR, Fung Kee, Fung KM. Tuberculous meningitis in pregnancy - implications for mother and fetus: case report and literature review. J Matern Fetal Med. 1999;8:289.

World Health Organization. Global tuberculosis report, 2014. Available at: http://apps.who.int/iris/bitstream/10665/137094/1/9789241564809 eng.pdf?ua=1.

M. Loto, Ibraheem Awowole. Tuberculosis in pregnancy. J Pregnancy. 2012;2012:379271.

Jana N, Vasishta K, Jindal SK, Khunnu B, Ghosh K. Perinatal outcome in pregnancies complicated by pulmonary tuberculosis. Int J Gynecol Obstet. 1994;44:119-24.

WHO. Guidelines for treatment for tuberculosis, 2010. Available at: http://www.who.int/tb/publications/2010/9789241547833/en/.

Cherian A, Thomas SV. Central nervous system tuberculosis. Afr Health Sci. 2011 Mar;11(1):116-27.

Kutlu T, Tugrul S, Aydin A, Oral O. Tuberculous meningitis in pregnancy presenting as hyperemesis gravidarum. J Matern Foetal Neonat Med. 2007 Apr;20(4):357-9.

Prasad K, Singh MB. Corticosteroids for managing tuberculous meningitis. Cochrane Database Syst Rev. 2008;(1):CD002244.

Sackoff JE, Pfieffer MR, Driver CR, Streett LS, Munsiff SS, DeHovitz JA. Tuberculosis prevention for non-U.S.-born pregnant women. Am J Obstet Gynecol. 2006;194:451-6.






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