Pregnancy outcome in women with polycystic ovary syndrome
DOI:
https://doi.org/10.18203/2320-1770.ijrcog20150449Keywords:
Polycystic ovarian disease, Gestational diabetes mellitus, Gestational hypertension, Preeclampsia, Preterm labourAbstract
Background: To compare the pregnancy outcome in polycystic ovary syndrome (PCOS) women with normal women and to study the incidence of pregnancy complications like spontaneous abortions, preterm labour, gestational diabetes, gestational hypertension, preeclampsia, pregnancy and neonatal outcome in women with PCOS.
Methods: Prospective comparative study done on 160 pregnant women to compare the pregnancy outcome in PCOS and normal women. All patients were subjected to detailed history, general and obstetric examination, antenatal investigations, routine dating scan, glucose challenge test at 24 to 28 weeks in study and control groups, blood pressure recording and urine for proteinuria after 20 weeks to evaluate preeclampsia. After delivery, birth weight and apgar score at 1 and 5 minutes are recorded. Body mass index is calculated and pregnancy outcome studied and compared.
Results: Out of 80 pregnancies with PCOS, 8 had spontaneous abortions, 11 Gestational diabetes mellitus (GDM), 9 gestational hypertension, 5 preeclampsia and 3 had preterm labour. GDM is 3 times, Spontaneous Abortion is 4.33 times, gestational hypertension is 3.25 times and neonatal intensive care unit (NICU) admission is 3.25 times more in PCOD women.
Conclusions: Pregnancy complications like spontaneous abortions, gestational diabetes, gestational hypertension and neonatal complications requiring NICU admissions are significantly higher in pregnant women with PCOD. Pregnant women with PCOD may become a high risk pregnancy at any time. Hence proper antenatal care is mandatory to prevent and treat the complications.
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References
Stein IF, Leventhal ML-Amenorrhea associated with bilateral polycystic ovaries. Am J Obstet Gynecol. 1935;29:181-91.
The Rotterdam ESHRE/ASRM-sponsored PCOS consensus workshop group. Revised 2003 consensus on diagnostic criteria and long term health risks related to polycystic ovary syndrome. Human Reprod. 2004;19:41-7.
Task Force on the Phenotype of the Polycystic Ovarian Syndrome of the Androgen Excess Society. Position Statement: The Androgen Excess Society evidence based criteria for defining the polycystic ovary syndrome as a predominantly hyperandrogenic syndrome. J Clin Endocrinal Metab. 2006;91:9237-45.
Jakubowitz DJ, Iuorno MJ, Jakubowicz S, Roberts KA, Nestler JE. Effects of metformin on early pregnancy loss in the polycystic ovary syndrome. J Clin Endocrinol Metab. 2002;87:524-9.
Glueck CJ, Philips H, Cameron D, Sieve-Smith L, Wang P-Continuing metformin throughout pregnancy in women with polycystic ovary syndrome appears to safely reduce first trimester spontaneous abortion: a pilot study. Fertil Steril. 2001;75:46-52.
Toulis KA. Risk of GDM in women with PCOS; a meta analysis. Fertility Sterility Journal. 2009;92:667-77.
Mikola M, Hiilesmaa V, Halttumen M, Suhomen L, Tiitinen A-Obsteric outcome in women with polycystic ovarian syndrome. Hum Reprod. 2001;16:226-9.
Bjercke S, Dale PO, Tanbo T, Storeng R, Ertzeid G, Abyholm T-Impact of insulin resistance on pregnancy complications and outcome in women with polycystic ovary syndrome. Gynecol Obstet Invest. 2002;54:94-8.
de Vries MJ, Dekker GA, Schoemaker J-Higher risk of preeclampsia in the polycystic ovary syndrome. A case control study. Eur J Obstet Gynecol Reprod Biol. 1998;76:91-5
Boomsa CM, Eijkemans MJ, Hughes EG, et al. A meta-analysis of pregnancy outcomes in women with polycystic ovary syndrome. Hum Reprod Update. 2006;12:673-83.