DOI: http://dx.doi.org/10.18203/2320-1770.ijrcog20150702

Evaluation of outcome of pregnancy in threatened abortion by serum progesterone levels

Rizwana Habib Kant, Shabnam Ara, Aamir Iqbal Lone, Shruti Gupta

Abstract


Background: Early pregnancy maintenance depends on the progesterone production by the developing trophoblasts of the placenta and the corpus luteum of ovary. Threatened abortion has a psychological impact on patients so we need to have a tool that could predict the outcome of threatened abortion in advance. Serum progesterone level has shown to be a reliable marker of pregnancy outcome. The aim of the study was to assess the correlation between maternal serum progesterone level and pregnancy outcome in threatened abortion and to assess the role of maternal serum progesterone levels in the immediate diagnosis of pregnancy failure.

Methods: This observational study was conducted in the Department of Gynaecology and Obstetrics, Lalla Ded Hospital, Government Medical College, Srinagar over a period of 1 year in 100 women presenting with threatened abortion of less than 12 weeks of gestation, having spotting but without cervical dilatation.  

Results: Mean maternal serum progesterone level in patients of threatened abortion who aborted was 21.5 ± 10.4 nanograms per millilitre and patients of threatened abortion who progressed normally to the period of viability had mean maternal serum progesterone level of 41.6 ± 10.8 nanograms per millilitre. Considering 24 nanograms per millilitre as cut off  limit, 19% of patients of threatened abortion were having serum progesterone level of lesser than or equal to 24 nanograms per millilitre and 81% of patients of threatened abortion were having serum progesterone level of greater than 24 nanograms per millilitre.  

Conclusions: Serum progesterone level is easy and reliable assay for determination of pregnancy outcome.


Keywords


Threatened abortion, Serum progesterone level, Period of viability

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References


Choudhary A, Khairthal (Alwar). Rajasthan, India. Type of abortion, 2008. Available at: http://www.typeof abortion.blogspot.com/2008,June.

Dongol A, Mool S, Tiwari P. Outcome of pregnancy complicated by threatened abortion. Kathmandu Univ Med J (KUMJ). 2011 Jan-Mar;9(33):41-4.

Lijun Duan A, Denglu Yan A, Weiyue Zeng A. Predictive power progesterone combined with beta human chorionic gonadotropin measurements in the outcome of threatened miscarriage. Arch Gynaecol Obstet. 2011;283:431-5.

Dutta DC. Endocrinology in relation to reproduction. 6th edition. New Delhi: Jaypee Brothers Medical Publishers; 2004;61:57-63.

Bowen R. Transcript of copy of Endocrine system. Placenta and ovaries, placental hormones, Vivo 6 Aug 2000. Available at: https://prezi.com/nbuzyu2w0jot/endocrine-system-placenta-and-ovaries/. Accessed 12 March 2008.

Abraham GE, Odell WB, Swerdloff RS, Hopper K. Simultaneous radioimmunoassay of plasma follicle stimulating hormone (FSH), luteinizing hormone (LH), progesterone, 17-hydroxyprogesterone, and estradiol 17-beta during the menstrual cycle. J Clin Endocrinol Metab. 1972;34(2):312-8.

Stefano Luis, Lucia Lazzari, Andrea Ricardio Genazzani. Endocrinology of pregnancy loss. In: Howard JA. Carp, eds. Recurrent Pregnancy Loss. 1st ed. US: CRC Press; 2008: 79-87.

Erickson GG. Normal ovarian function. Clin Obstet Gynecol. 1978;21(1):31-53.

Sugita N, Yamaji K, Fujita M, Chiba Y, Otsuki Y, Takagi T, et al. Serum human chorionic gonadotropin (HCG), human placental lactogen (HPL) and progesterone levels in threatened abortions. Nihon Sanka Fujinka Gakkai Zasshi. 1980;32(7):851-8.

Friedrich FH, Salzer H, Kemeter P. Detection of progesterone in serum. Clinical significance in early pregnancy. Fort Schr Med. 1984;102(41):1053-5.

Witt BR, Wolf GC, Weeknight CJ, Johnston PD, Thorneycroft IH. Relaxin, CA-125, progesterone, estradiol, Schwangerschaft protein, and human chorionic gonadotropin as predictors of outcome in threatened and non-threatened pregnancies. Fertil Steril. 1990;53(6):1029-36.

Mathews CP, Coulson PB, Wild RA. Serum progesterone levels as an aid in the diagnosis of ectopic pregnancy. Obstet Gynecol. 1986;68(3):390-4.

Hubinont CJ, Thomas C, Schwers JF. Luteal function in ectopic pregnancy. Am J Obstet Gynecol. 1987;156(3):669-74.

Zainab Ali Abdulla AI Jufairi. The value of serum progesterone measurement in early pregnancy. Bahrain Med Bull. 2000;22(1):1-5.

Chhabria S, Ghosh UK. Role of serum progesterone in cases of threatened abortion. J Obstet Gynaecol. 1996 Sep;46(5):609-13.

Vahid Roudsari, Fatemeh, Ayati S, Heydari F. A comparison of serum progesterone levels in normal pregnancy and threatened abortion under 12 weeks of gestation. Iran J Obstet Gynaecol Infertil. 2002;5(2):16-22.

Lijun Duan A, Denglu Yan A, Weiyue Zeng A. Predictive power progesterone combined with beta human chorionic gonadotropin measurements in the outcome of threatened miscarriage. Arch Gynaecol Obstet. 2011;283:431-5.

M. Khanam, Nahid Yousuf, Fatima Ashraf. Outcome of threatened abortion in a series of 100 cases of RMCH. J Teachers Assoc RMC Rajashahi. 2005;18(2):76-9.

Hanita O, Hanisah AH. Potential use of single measurement of serum progesterone in detecting early pregnancy failure. Malaysian J Pathol. 2012;34(1):41-6.

Midha U, Narang APS, Sofat IB, Anasthi K, Jain M. Serum progesterone levels in abortion. J Obstet Gynaecol. 2002;52(5):47-50.

Maraghy MA EI, Lami H, Pinkerton JH, Sheridan B. The prognostic value in threatened abortion of plasma progesterone values and the cornification index of vaginal smears. Br J Obstet Gynaecol. 1978;85(7):533-5.