Comparative study of sublingual and vaginal misoprostol in second trimester induced abortion
DOI:
https://doi.org/10.18203/2320-1770.ijrcog20150675Keywords:
Misoprostol, Second trimester pregnancy termination, Sublingual route, Vaginal route, Abortion, Midtrimester AbortionAbstract
Background: To recognize an effective Misoprostol only regime and to compare the efficacy, safety and acceptability of sublingual and vaginal Misoprostol for the termination of second trimester of pregnancy.
Methods: The study was a prospective randomized trial. Women attending OPD from January2012 to December 2013, for medical abortion between gestational ages 13-20 weeks were screened, selected and divided in to two groups. Group-A received misoprostol 400 µg then 200 µg sublingually 3 hourly, Group-B received misoprostol 400 µg then 200 µg vaginally 3 hourly. They were observed for 24 hours. Main outcomes were induction-abortion interval, dose required, success rate and side effects and comfort to the route of administration.
Results: Mean induction-abortion interval was 9.28 ± 5.824 hours, 95% CI: 7.62-10.94in sublingual misoprostol group and 13.68 ± 6.179 hours, 95% CI: 11.92-15.44 in vaginal group. Mean dose required for abortion was 948 ± 389.264 µg, 95% CI: 837.37-1058.63 in sublingual and 1248 ± 415.142 µg, 95% CI: 1,130.02-1,365.98in vaginal group. Success rate was 98% and 94%, respectively in two groups. The differences were statistically significant. Comfort to the route of administration was 90% in sublingual and 60% in vaginal group.
Conclusions: Both sublingual and vaginal routes of Misoprostol are equally effective, safe, inexpensive and acceptable method. Sublingual route is better and preferred by women.References
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