Vaginal discharge: evaluation of syndromic management in Chhattisgarh Institute of Medical Sciences, Bilaspur, C.G.
DOI:
https://doi.org/10.18203/2320-1770.ijrcog20150691Keywords:
Vaginal Discharge, Syndromic management, Combination kit therapy, STDAbstract
Background: Vaginal discharge is one of the most common problems faced by women. It may be physiological or pathological. Most of the time it caused by bacteria, fungi or parasites and many times these infections are sexually transmitted. Thus it is important to treat vaginal discharge as syndrome. Syndromic management is an inexpensive and effective method to treat vaginal discharge and no preliminary laboratory test are required. We have studied 300 patients attending OPD with complain of vaginal discharge to access the efficiency, acceptability and tolerance of one day combination kit therapy (azithromycin 1 g, fluconazole 150 mg and Secnidazole 2 g).
Methods: Three hundred women were selected randomly with the complaint of vaginal discharge.
They were examined thoroughly and advised to take one day kit therapy. Their partners were also advised to take same therapy. They were called after two weeks to know about their symptoms and for examination.
Results: Sixty percent women had excellent response for vaginal discharge, 75% women had excellent response for urinary symptoms and 77.3% women had excellent response for pruritus vulvae.
Conclusions: The combination kit therapy in vaginal discharge allows a simple and fast assured therapy, with high cure rate for vaginal discharge.
References
World Health Organization. Guideline for the management of sexually transmitted infection. Geneva. WHO, 2001.
Chesson HW, Pinkerton SD. sexually transmitted diseases and the increased risk for HIV transmission: implications forcost-effectiveness analyses of sexually transmitted disease prevention interventions. J Acquir Immune Defic Syndr. 2000;24(1):48-56.
Karaca M, Bayram A, Kocoglu ME, Gocmen A, Eksi F. Comparison of clinical diagnosis and microbiological test results invaginal infections. Clin Exp Obstet Gynecol. 2005;32(3):172-4.
Gil lis JC, Wiseman LR. Secnidazole. A review of its antimicrobial activity, pharmacokinetic properties and therapeutic use in the management of protozoal infections and bacterial vaginosis Drugs. 1996;51(4):621-38.
Rossignol JF, Maisonneuve H, Cho YW. Nitroimidazoles in the treatment of trichomoniasis, giardiasis, and amebiasis. Int J Clin Pharmacol Ther Toxicol. 1984;22(2):63-72.
A comparison of single-dose oral fluconazole with 3-day intravaginal clotrimazole in the treatment of vaginal candidiasis. Report of an international multicenter trial. Br J Obstet Gynaecol. 1989;96(2):226-32.
Pitsouni E, lavazzo C, A Thanasiou S, Falagas ME. Single-dose azithromycin versus erythromycin or amoxicillin for Chlamydia trachomatis infection during pregnancy: a meta-analysis of randomized controlled trials. Int J Antimicrob Agents. 2007;30(3):213-21.
Pepin J, Sobela F, Khonde N, Agyarko-Poku T, Diakite S, Deslandes S, et al. The syndromic management of vaginal discharge using single-dose treatments: a randomized controlled trial in West Africa. Bull World Health Organ. 2006;84(9):729-38.
Jacob Bornstein, Doron Zafate. A universal combination treatment for vaginitis, A randomized controlled trail. Gynecol Obstel Invest. 2008;65:195-200.
Sabir S, Hussan L. Outcome of syndromic management in case of chronic vaginal discharge. JPM. 2010;24(03):234-8.
Kissinger P, Mena LA. Randomized treatment trial ,single versus 7 days dose of Metronidazole for treatment of Trichomonas vaginalis among HIV infected women. J Acquir immune defic syndr. 2010;55(5):567-71.
Onyekown CL, Olumide Y, Oresanya F. Vaginal Discharge: Etiological Agents and evaluation of Syndromic management in Lagos. Niger J Med. 2011;20(1):155-62.
Milsana K, Naicker N, Werner L, Roberts L, et al. Symptomatic vaginal discharge in a poor predictor of sexually transmitted infections and genital tract inflammation in high risk women in South Africa. J Infect Dis. 2012;206(1):6-14.
Lewis DA, Kimberly M, Frans R. Trends and association of trichomonad vaginalis infection women with genital discharge syndrome in Johannesburg South Africa. Sex Trans Infect. 2013;10:1136.
Parmar MT, Harsha M. A study of Prevalence of sexually transmitted infection and response to syndromic treatment among married women of reproductive age group in rural area of Parol primary health centre under Thane district. Global Journal of Medicine and Public Health. 2013;2(2):480-4.
Sena AC, Bachman LH, Hobb M. Persistant and recurrent Trichomonas Vaginalis infection: Epidemiology, treatment and management consideration. Expert Rev Anti Infective therapy. 2014;12(6):673-85.
Nazmul A, Malay K, Kristensen S. Knowledge and skill for management of sexually transmitted infection by rural medical practitioners in Bangladesh. Open Journal of Preventive medicine. 2015;5:151-8.
Maladkar M, Tekchandani C, Dave U. Clindamycine, clotrimazole and Tinidazole in Mixed vaginosis-A real world clinical experience.Journal of Gynaecology and Obstetrics. 2015;3(3):49-54.
