DOI: http://dx.doi.org/10.18203/2320-1770.ijrcog20150750

Rh sensitized pregnancy with high ICT titre wit favourable foetal outcome: a rare case

Namrata Saxena, Manju Lal, Navneet Kumar Bhat, Mansi Sachdev

Abstract


Leiomyosarcoma Rhesus (Rh) isoimmunization is the development of maternal IgG antibodies against fetal Rh Red Blood Cell (RBC) antigens. Transplacental passage of maternal Rh antibody (IgG anti-D) may result in Hemolytic Disease of the Newborn (HDN), a condition characterized by hemolysis, severe fetal anemia and generalized fetal edema (hydrops fetalis). The severity of Rh hemolytic disease may be assessed in the Immunized patient by several different means which include: past obstetric history, maternal antibody titer, ultrasonography, amniotic fluid bilirubin quantification, and percutaneous umbilical blood sampling. A past history of fetal demise, hydrops fetalis, intrauterine transfusion or neonatal exchange transfusion implies that the present pregnancy is or will be severely affected because Rh disease effects on the fetus generally recur or present progressively earlier or more severely with each successive Rh positive pregnancy. We present here a rare case of Rh sensitized pregnancy with high ICT titre who had normal fetal outcome.


Keywords


Rhesus (Rh) isoimmunization, Favourable outcome, Indirect Coomb test (ICT)

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References


McLean LK, Hedriana HL, Lanouette JM, Hanns C, Haesslein. A retrospective review of isoimmunised pregnancies managed by middle cerebral artery peak systolic velocity. Am J Obstet Gynecol. 2004;190:1732-8.

Cacciatore A, Rapiti S, Carrara S, Cavaliere A, Ermito S, Dinatale A, et al. Obstetric management in Rh alloimmunizated pregnancy. J Prenat Med. 2009;3(2):25-7.

Bullock R1, Martin WL, Coomarasamy A, Kilby MD. Prediction of fetal anemia in pregnancies with red-cell alloimmunization: comparison of middle cerebral artery peak systolic velocity and amniotic fluid OD450. Ultrasound Obstet Gynecol. 2005;25(4):331-4.

Moise KJ Jr. Management of rhesus alloimmunization in pregnancy. Obstet Gynecol. 2002;100(3):600-11.

Acharya S, Ahmed S. A case of pregnancy with rhesus antibody and bicornuate uterus - a favourable outcome:a case report. Cases J. 2010;3:50.