Epidemiological study of clinical characteristics of patients with PCOS attending infertility clinic and awareness of PCOS in a rural set up
Keywords:Polycystic ovarian syndrome, Awareness, Infertility
Background: Polycystic ovarian syndrome (PCOS) is one of the most common endocrine disorders in women of reproductive age group.It is a common diagnosis in women presenting with infertility.All the dimensions of PCOS have not been completely explored.In this study we studied the clinical features of PCOS and comparing with non-PCOS infertility patients and simultaneously studied the prevalence of PCOS in infertility patients and its awarenessin a rural set up.
Methods:It is a prospective observational study carried out over a period of 15 months at infertility clinic Acharya Vinoba Bhave Rural Hospital in Maharashtra,India in 100 infertility patients.
Results:54 out of 100 infertility patients had PCOS.16 out of 54 had oligomenorrhoea in contrast to 10 out of 46 in non PCOS.38 PCOS patients had multiple follicles which only 18 non PCOS had.There was a significant difference in androgenic features of PCOS and non PCOS but not in BMI and WHR. Only 10 patients were aware regarding PCOS.
Conclusion:PCOS is one of the important factors causing infertility.It is an ill defined symptom complex needing its due attention.There is a need to increase awareness regarding.The clinical featuresof PCOS are heterogeneous and thus can be investigated accordingly of selection of appropriate treatment modality.
Stein IF, Leventhal ML. Amennorhoea associated with bilateral polycystic ovaries. Am J Obstet Gynecol. 1953;29:181.
The Rotterdam ESHRE/ASRM-sponsored PCOS consensus workshop group. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome. Fertil Steril. 2004;11:19–25.
Dunaif A. Insulin resistance and the polycystic ovary syndrome: Mechanism and implications for pathogenesis. Endorcr Rev.1997;18:774-800.
Franks S. Polycystic ovary Syndrome: a changing perspective. Clin Endocrinol (Oxf). 1989;31:87-120.
Dunaif A, Graf M, Mandeli J, Laumas V, Dobrjansky A. Characterization of groups of hyperandrogenic women with acanthosis nigricans, impaired glucose tolerance, and/.or hyperinsulinemia. J Clin Endocrinol Metab. 1987;65:499-507.
Pasquali R, Gambineri A, Pagotto U. The impact of obesity on reproduction in womenwith polycystic ovary syndrome. BJOG. 2006;113:1148-1159.
Kiddy DS, Hamilton-Fairley D, Bush A, Short F, Anyaoku V, Reed MJ, et al. Improvement in endocrine and ovarian function during dietary treatment of obesewomen with polycystic ovary syndrome. Clin Endocrinol (Oxf). 1992;36:105-111.
Holte J, Bergh T, Berne C, Wide L, Lithell H. Restored insulin sensitivity but persistently increased early insulin secretion after weight loss in obese women with polycystic ovary syndrome. J Clin Endocrinol Metab. 1955:80:2586-2593.
Misra A, Chowbey P, Makkar BM, Vikram NK, Wasir JS, Chadha D, et al. Consensus statement for diagnosis of obesity, abdominal obesity and the metabolic syndrome for Asian Indians and recommendations for physical activity, medical and surgical management. J Assoc Physicians India. 2009;57:163–70.
Hatch R, Rosenfield RL, Kim MH, Tredway D. Hirsutism: Implications, etiology, and management. Am J Obstet Gynecol.1981;140:815–30.
NaderS.Adrenarche and polycystic ovary syndrome:A tale of two hypothesis. J Pediatr Adolesc Gynaecol. 2007;20:353-60.
Solomon CG, Hu FB, Dunaif A, Rich-Edwards J, Willett WC, Hunter DJ, et al. Long or highly irregular menstrual cycles as a marker for risk of type2 diabetes mellitus, JAMA. 2001;286:2421-6.
Majumdar A, Singh TA. Comparison of clinical features and health manifestations in lean vs obese Indian women with polycystic ovarian syndrome. J Hum Reprod Sci. 2009;2:12-7.
Pfeifer SM, Kives S. Polycystic ovary syndrome in the adolescent. Obstet Gynecol Clin North Am. 2009;36:129-52.