Liver ailments in pregnancy: our experience

Authors

  • Uttara Aiyer Kohli Department of Obstetrics and Gynecology, Armed Forces Medical College, Pune, Maharashtra, India
  • Atul Seth Department of Obstetrics and Gynecology, Armed Forces Medical College, Pune, Maharashtra, India
  • Sanjay Singh Department of Obstetrics and Gynecology, Armed Forces Medical College, Pune, Maharashtra, India
  • Rajesh Mishra Department of Obstetrics and Gynecology, Armed Forces Medical College, Pune, Maharashtra, India

DOI:

https://doi.org/10.18203/2320-1770.ijrcog20170560

Keywords:

AFLP, HELLP, Liver, Preeclampsia, Pregnancy

Abstract

Background: The spectrum of liver disease is varied and is associated with increased maternal and perinatal morbidity and mortality when pregnancy coexists with the liver disease. This study aims to analyze the incidence, spectrum, clinical presentation and outcome of liver diseases complicating pregnancy

Methods: A retrospective cohort study was conducted and data was collected from the hospital records of obstetric cases diagnosed with liver disease complicating pregnancy in a tertiary care hospital, over a period of two years.

Results: A total 146 cases of liver diseases complicating pregnancies were recorded out of 5018 deliveries (2.9%). Intrahepatic cholestasis of pregnancy (n=52, 35.62%) and severe preeclampsia (n=47, 32.19%, with HELLP n=8, 5.48%) accounted for majority of cases. The incidence of chronic hepatitis B infection was 20.56% (n=30). There were two maternal deaths (1.37%) attributed to severe post-partum HELLP and severe preeclampsia with multi organ failure.

Conclusions: Liver diseases in pregnancy have a non-specific presentation and may be associated with a wide range of conditions, early diagnosis and timely appropriate intervention can help reduce the mortality and morbidity.

References

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Published

2017-02-19

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Section

Original Research Articles