Histopathological study of precursor and neoplastic lesions of endometrium in endometrial samplings

Nanda J. Patil; Heena P. Shah; Mamta Bharti

doi:10.18203/2320-1770.ijrcog20170571

Authors

Nanda J. Patil Department of Pathology, Krishna Institute of Medical Sciences, Karad, Satara, Maharashtra, India
Heena P. Shah Department of Pathology, Krishna Institute of Medical Sciences, Karad, Satara, Maharashtra, India
Mamta Bharti Department of Pathology, Krishna Institute of Medical Sciences, Karad, Satara, Maharashtra, India

DOI:

https://doi.org/10.18203/2320-1770.ijrcog20170571

Keywords:

AUB, Endometrial hyperplasia, Neoplastic lesion, Precursor lesion

Abstract

Background: Endometrial lesion presenting as abnormal uterine bleeding, abdominal pain and menstrual irregularities form most common presenting complaint in women of reproductive age group and in premenopausal women. Endometrial sampling is a safe and effective diagnostic step in evaluation of abnormal uterine bleeding (AUB). The present study was carried out to establish histopathological diagnosis of precursor and neoplastic lesions of endometrial samplings in correlation with clinical details and other investigations.

Methods: A two-year prospective study was carried out in the department of pathology in a tertiary care hospital from June 2013-May 2015 which included endometrial samplings of precursor and neoplastic lesions. All cases were analyzed histopathologically.

Results: The study included 46 cases comprising 30% of total 153 endometrial samplings. Out of these, precursor lesions were 36 cases (23.6%) and malignant were 10 case (5.8%). The highest incidence of precursor lesions (endometrial hyperplasia) was in the age group of 41- 50 years. Among the precursor lesions, endometrial hyperplasia without atypia (86%) was the commonest observation followed by atypical hyperplasia (14%).

Conclusions: For the correct evaluation of cases presenting with AUB, histopathological evaluation of endometrial samplings is the gold standard method.

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References

Lampe B, Kirzl R, Hantschmann P. Reliability of tumour typing of endometrial carcinoma in prehysterectomy curettage. Int J Gynecol Pathol. 1995;14:2-6.

Doraiswami S, Johnson T, Rao S, Rajkumar A, Vijayaraghavan K, Panicker VK. Study of endometrial pathology in abnormal uterine bleeding. J Obstet Gynecol India. 2011;61(4):426-30.

Jagdale A, Sharma A. Histopathological study of endometrium in abnormal uterine bleeding in relation to different age groups, parity and clinical symptomatology. Int J Clin and Biomed Res. 2015;1(2):90-95.

Dadhania B, Dhruva G, Agravat A, Pujara K. Histopathological study of endometrium in dysfunctional uterine bleeding. Int J Res Med. 2013;2(1):20-24.

Agarwal S, Mathur A, Vaishnav K. Histopathological study of endometrium in abnormal uterine bleeding in women of all age groups in western Rajasthan (400 cases). Int J Basic and Applied Med Sci. 2014;4(3):15-18.

Moghal N. Diagnostic value of endometrial curettage in abnormal uterine bleeding - a histopathological study. J Pak Med Assoc. 1997;47(12):2959.

Baral R, Pudasini S. Histopathological pattern of endometrial samples in abnormal uterine bleeding. J Path Nepal. 2011;1:13-6.

Abid M, Hashmi AA, Malik B, Haroon S, Faridi N, Edi MM, et al. Clinical pattern and spectrum of endometrial pathologies in patients with abnormal uterine bleeding in Pakistan: need to adopt a more conservative approach to treatment. BMC Women’s Health. 2014;14:132.