Prevalence of thyroid disorders among patients attending the antenatal clinic at tertiary care centre, Parel, Mumbai, India


  • Jaya Kundan Gedam Department Obstetrics and Gynaecology, ESI PGIMSR MGM Hospital, Parel, Mumbai, Maharashtra, India
  • Disha A. Rajput Department Obstetrics and Gynaecology, ESI PGIMSR MGM Hospital, Parel, Mumbai, Maharashtra, India



Antenal women, Overt hyperthyroidism, Overt hypothyroidism, Subclinical hyperthyroidism, Subclinical hypothyroidism, Thyroid disorder


Background: Pregnancy is associated with major changes in the physiology of the thyroid gland. Undiagnosed thyroid disorders can adversely affect fetal and maternal outcome. This study was done to study the prevalence of thyroid disorder among antenatal women.

Methods: This was a prospective study done in the antenatal clinic in the Department of Obstetrics and Gynaecology, ESI PGIMSRMGM Hospital, Parel, Mumbai, India.

Results: In present study, fifty out of three hundred and fifty pregnant women screened had thyroid disorder. The prevalence of thyroid disorder in this study was 14.2%. The prevalence of subclinical hypothyroidism was 7.7% (n= 27), overt hypothyroidism was 4% (n=14), subclinical hyperthyroidism was 1.7% (n=6) and overt hyperthyroidism was 0.8% (n=3).

Conclusions: Thyroid disorders in pregnancy are associated with adverse fetomaternal outcome. Its prevalence is high in Indian women. Thus thyroid screening should be included in the routine antenatal investigations.


LeBeau SO, Mandel SJ. Thyroid disorders during pregnancy. Endocrinol Metab Clin North Am. 2006;35:117-36.

Nambiar V, Jagtap VS, Sarathi V, Lila AR, Kamalanathan S, Bandgar TR, et al. Prevalence and impact of thyroid disorders on maternal outcome in Asian-Indian pregnant women. J Thyroid Res. 2011;2011:4290-7.

Sahu MT, Das V, Mittal S, Agarwl A, Sahu M. Overt and subclinical thyroid dysfunction among Indian pregnant women and its effect on maternal and fetal outcome. Arch Gynecol Obstet. 2010;281:215-20.

Ogunyemi DA. Autoimmune thyroid disease and pregnancy. eMedicine website. . Updated April 23, 2010. Accessed August 11, 2011.

Komal PS, Mestman JH. Graves hyperthyroidism and pregnancy: a clinical update. Endocrine Practice. 2010;16(1):118-2.

Montoro MN. Management of hypothyroidism during pregnancy, Clin Obstat Gynecol. 1997;40:65-80.

Stagnaro-Green A. Thyroid antibodies and miscarriage: Where are we a generation later? J Thyroid Res. 2011;2011:841-49.

Wang W, Teng W, Shan Z, Wang S, Li J, Zhu L, et al. The prevalence of thyroid disorders during early pregnancy in China: The benefits of universal screening in the first trimester of pregnancy. Eur J Endocrinol. 2011;164:263-8.

Thanuja PM, Rajgopal K, Sadiqunnisa. Thyroid dysfunction in pregnancy and its maternal outcome. Journal Dental and Medical Sciences (IOSR-JDMS): 2279-0861. 2014;13(1):11-5.

Rao S, Patibandla A. A Study to find out the Prevalence of Hypothyroidism among Pregnant Women Visiting ESI Hospital Sanathnagar Hyderabad. Gynecol Obstet. 2016;6:363.

Casey BM, Dashe JS, Wells CE, McIntire DD, Byrd W, Leveno KJ, Cunningham FG. Subclinical hypothyroidism and pregnancy outcomes. Obst Gynec. 2005;105(2):239-45.

Dhanwal DK, Sudha P, Agarwal AK, Dixit V, Banerjee AK. High prevalence of subclinical hypothyroidism during first trimester of pregnancy in North India. Ind J Endocrinol Metab. 2013;17:281-4.

Murty Nabhi VR, Bhashyakarla U. Prevalence of Thyroid Dysfunction among Pregnant Women in a Rural Teaching Hospital in Telengana, South India Scholars. Journal of Applied Medical Sciences. 2014;2(6B):2022-5.

Mannisto T, Vaarasmaki M, Pouta A, Hartikainen AL, Ruokonen A, Surcel HM, Bloigu A, et al. Thyroid dysfunction and maternal morbidity. J Clin Endocrinol Metab. 2010;95(3):1084-1094.

Stagnaro GA. Overt Hyperthyroidism and Hypothyroidism during pregnancy. Clin Obstet Gynaecol. 2011;54(3):478-82.

Teng X, Shan Z, Chen Y, Lai Y, Yu J, Shan L, et al. More than adequate iodine intake may increase subclinical hypothyroidism and autoimmune thyroiditis: A cross-sectional study based on two Chinese communities with different iodine intake levels. Eur J Endocrinol. 2011;164:943-50.

Marwaha RK, Tandon N, Gupta N, Karak AK, Verma K, Kochupillai N. Residual goitre in the postiodization phase: Iodine status, thiocyanate exposure and autoimmunity. Clin Endocrinol (Oxf). 2003;59:672-81.

Das S, Bhansali A, Dutta P, Aggarwal A, Bansal MP, Garg D, et al. Persistence of goiter in the postiodization phase. Micronutrioent deficiency or thyroid autoimmunity? Indian J Med Res. 2011;133:103-9.






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