Published: 2017-04-27

A study of thyroid dysfunction in dysfunctional uterine bleeding

Santosh Kumar Verma, Anita Pal, Saroj Jaswal


Background: The objective of the study was to evaluate the prevalence of thyroid dysfunction in dysfunctional uterine bleeding and to assess the menstrual and endometrial pattern in women with thyroid disorders.

Methods: The present study was conducted on 200 patients who presented with dysfunctional uterine bleeding in gynecology OPD.

Results: Among the 200 women 39 (19.5%) had hypothyroidism, 2 (1%) had hyperthyroidism and 159 (79.55%) were euthyroid. Menorrhagia was the most common menstrual disorder in hypothyroidism and oligomenorrhoea in hyperthyroidism. In the present study 74.3% patients had proliferative endometrium,26.3% secretory endometrium, in hypothyroid patients and secretory endometrium in 2 (1%) hyperthyroid patients. A woman with hypothyroidism, commonly presents with anovulation and unopposed oestrogen activity causes endometrial hyperplasia which may outgrow the blood supply and may cause local areas of necrosis and breakdown and produces bleeding.

Conclusions: The menstrual irregularities are significantly more frequent in patients with thyroid dysfunction and menorrhagia was the commonest menstrual abnormality. The study concludes that biochemical evaluation of thyroid function should be made mandatory in all cases of abnormal uterine bleeding and this would avoid unnecessary surgeries and exposure to hormones.


Abnormal uterine bleeding, Dysfunctional uterine bleeding, Menorrhagia, Oligomenorrhoea, Thyroid dysfunction

Full Text:



Butler WJ. Normal and abnormal uterine Rock JA and Jones HW. Telinde’s operative gynaecology. 9th edition. PhiladelpShia:Lippinocot Williams and Wilkins;2003:457-78.

Davey DA. Dysfunctional uterine bleeding. In Charles R Whitfield Textbook of obstetrics and gynaecology for postgraduates .5th edition. printed by Bombay Oxford University Press, Delhi;1995:590-607.

Talukdar B, Mahela S. Abnormal uterine bleeding in perimenopausal women: correlation with sonographic findings and histopathological examination of hysterectomy specimen. J Mid-Life Health. 2016;7:73-7.

Lopez J. Pathophysiology of dysfunctional uterine bleeding. In: Purandare CN, Khadilkar S. Dysfunctional uterine bleeding - An update. First edition. New Delhi. Jaypee Brothers;2004:16-23.

Sharma N, Sharma A. Thyroid profile in menstrual disorders. JK Sci. 2012;14(1):14-7.

Ajmani NS, Sarbhai V, Yadav N, Paul M, Ahmad A, Ajmani AK. Role of thyroid dysfunction in patients with menstrual disorders in tertiary care center of walled city of Delhi. J Obstet Gynaecol India. 2016;66(2):115-9.

Ross GT, Scholz DA, Lambert EH, Geraci. Severe uterine bleeding and degenerative skeletal muscle changes in unrecognized myxoedema. J Clin Endocrinol. 1958;18:492-500.

Speroff L, Fritz MA. Reproduction and thyroid . In: clinical gynaecologic endocrinology and Infertility. 7th Ed. Philadelphia:Lippincott Williams & Wilkins; 2005:805-821

Bhavani N, Sathineedi A, Chippa S, ReddyVSP. A study of correction between abnormal uterine bleeding and thyroid dysfunction. International J Recent Trends Sci Tech. 2015;14(1):131-5.

Pilli GS, Sethi B, Dhaded AV, Mathur PR, Dysfunctional uterine bleeding. J Obstet Gynaecol India. 2001;52(3):87-9.

Sowers M, Luborsky J, Perdue C et al.thyroid stimulating Hormone(TSH)concentrations and menopausal status in women at the mid-life. J Clin Endocrinol. 2003;58:340-7.

Pahwa S, Shailja G,Jasmine K. Thyroid dysfunction in dysfunctional uterine bleeding. J Adv Research Biologic Sci. 2013;5(1):78-83.

Scott JC, Mussey E. Menstrual patterns in myxoedema.Am J Obstet Gynaecol. 1964;90:161-5.

Kaur T, Aseeja V, Sharma S. Thyroid Dysfunction in dysfunctional uterine bleeding. Webmed Central Obstet Gynaecol. 2011;2(9):002235.

Goldsmith RE, Sturgis SH, Lerman J, Stanbury JB Menstrual pattern in thyroid disease. J Clin Endocrinol. 1952;12:846-55.

Padmaleela K, Thomas V, Lavanya KM, Kiranmai D. Thyroid disorders in dysfunctional uterine bleeding (DUB) among reproductive age group women-a cross-sectional study in a territory care hospital in Andhra Pradesh India. Int J Med Pharma Sci. 2013;(1):41-6.

Wilansky DL, Greisman B. Early hypothyroidism in patients with menorrhagia. Am J obstet. Gynaecol 1989;160:673-77.

Sruthi T, Shivanna S, Gopal N. Prevalence of hypothyroidism in patients with provisional Diagnosis of DUB. J Eval Medic Dent Sci. 2014;3(11):2967-72