Published: 2017-05-25

LDH as a prognostic marker in hypertensive pregnancy

Prathap Talwar, Triveni Kondareddy, Pranidha Shree C. A.


Background: Pregnancy induced hypertension (PIH) is a global problem with a 5-15% incidence rate in India and complicating 10-17% of all pregnancies. These are multisystem disorders and lead to a lot of cellular death. LDH is an intracellular enzyme and its level is increased in these women due to cellular death. So, serum LDH levels can be used to assess the extent of cellular death and thereby the severity of disease in this group of women. The objective of the study was to correlate the severity of the disease, maternal and perinatal outcome with Lactic Dehydrogenase (LDH) levels in serum in patients of preeclampsia and eclampsia.

Methods: A prospective comparative study was conducted in the department of Obstetrics and Gynecology, JSS Medical Hospital, Mysore.

Results: LDH levels were significantly elevated in women with preeclampsia and eclampsia (<0.001). Higher LDH levels had significant correlation with high blood pressure (P <0.10) as well as poor maternal and perinatal outcome.

Conclusions: High serum LDH levels correlate well with the severity of the disease and poor outcomes in patients of preeclampsia and eclampsia.


Eclampsia, prognosis, Lactic Dehydrogenase, Preeclampsia

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Mackey AP, Berg CJ, Atrash HK. Pregnancy related mortality from preeclampsia and eclampsia. Am J Obstet Gynecol. 2001;97(4):533-8.

Shah MR. Hypertensive disorders in pregnancy. 1st edn published by Jaypee. 2007:1-10.

Qublan HS, Amarun V, Bateinen O, Al-Shraideh Z, Tahat Y, Awamleh I, et al. LDH as biochemical marker of adverse pregnancy outcome in severe preeclampsia. Med Sci Monit. 2005;11:393-7.

Pennington KA, Schlitt JM, Jackson DL, Schulz LC, Schust DJ. Preeclampsia: multiple approaches for a multifactorial disease. Dis Model Mech. 2012;5(1):9-18. stet Gynecol. 2001;97(4):533-8.

Jaiswar SP, Gupta A, Rekha S, Natu SN, Shaili Mohan. Lactic Dehydrogenase: A biochemical marker for preeclampsia-eclampsia. JOGI, 2011; 61(6):645-8.

Sarkar PD, Sogani S. Evaluation of serum lactate dehydrogenase and gamma glutamyl transferase in preeclamptic pregnancy and its comparison with normal pregnancy in third trimester. Int J Res Med Sci. 2013;1(4):365-8.

Aziz R, Mahboob T. Relation between preeclampsia and cardiac enzymes. ARYA Atheroscler J. 2008; 4(1):29-32.

Al-Jameil N, Tabassum H, Al-Mayouf H, Al-Otay L, Khan FA. Liver function tests as probable markers of preeclampsia-A prospective study conducted in Riyadh. JCAM. 2013:1-4.

Munde SM, Hazari NR, Thorat AP, Gaikwad SB, Hatolkar VS. Gamma glutamyl transferase and Lactate dehydrogenase as biochemical markers of severity of preeclampsia. Int J Med Health Pharm Biomed Eng. 2014;8(1):50-3.

Wagner LK. Diagnosis and management of preeclampsia. Am Fam Physician. 2004;70(12): 2317-24.

Bera S, Gupta S, Roy SS, Kunti S, Biswas S, Ghosh D. Study of liver enzymes especially lactateinduced hypertension. Sch J App Med Sci. 2014;2(5A):1569-72.

Staff AC, Benton SJ, Dadelszen PV, Roberts JM, Taylor RN, Powers RWD. et al. Redefinining preeclampsia using placenta-derived biomarkers. Hypertens. 2013;61:932-42.

Var A, Yildirim Y, Onur E, Kuscu NK, Uyanik BS, Goktalay K, et al. Endothelial dysfunction in preeclampsia. Gynecol Obstet Invest. 2003;56:221-4.

Petla LT, Chikkala R, Ratnakar KS, Kodati V, Sritharan V. Biomarkers for the management of pre-eclampsia in pregnant women. Indian J Med Res. 2013;138:60-7.

Dutta DC. Text Book of Obstetrics. 6th ed. Calcutta: New Central Book Agency (P) Ltd; 2008:666.

Sonagra AD, Dattatreya K, Murthy JDS. Serum LDH, ALP and Uric Acid in hypertensive disorders of pregnancy. IJPBS. 2012;2(3):201-9.

Kozic JR, Benton SJ, Hutcheon JA, Payne BA, Magee LA, Dadelszen PV. Abnormal liver function tests as predictors of adverse maternal outcomes in women with preeclampsia. JOGC. 2011;33(10): 995-1004.