A rare case of mixed germ cell tumor in a teenage girl: a case report

Authors

  • Faraz S. Vali Department of Obstetrics and Gynecology, Medical College and Hospital, Kolkata, West Bengal, India http://orcid.org/0000-0002-2667-9248
  • Amit Kyal Department of Obstetrics and Gynecology, Medical College and Hospital, Kolkata, West Bengal, India
  • Parul I. Chaudhary Department of Obstetrics and Gynecology, Medical College and Hospital, Kolkata, West Bengal, India
  • Sujatha Das Department of Obstetrics and Gynecology, Medical College and Hospital, Kolkata, West Bengal, India
  • Aprateem Mukherjee Department of Obstetrics and Gynecology, Medical College and Hospital, Kolkata, West Bengal, India
  • Partha Mukhopadhyay Department of Obstetrics and Gynecology, Medical College and Hospital, Kolkata, West Bengal, India

DOI:

https://doi.org/10.18203/2320-1770.ijrcog20172378

Keywords:

Embryonal cancer, Mixed germ cell tumor, Non-gestational choriocarcinoma, Yolk sac tumor/endodermal sinus tumor

Abstract

Germ cell tumors represent only 20% to 25% of all benign and malignant ovarian neoplasms. Mixed germ cell tumors are a rare variety of non–dysgerminomatous germ cell tumors. They contain two or more elements; the most frequent combination being a dysgerminoma and an EST (Endodermal Sinus Tumor). We present a case of malignant mixed germ cell tumor comprising of yolk sac tumor, embryonal carcinoma and choriocarcinoma. A 13-year-old girl presented with a huge 25 x 18 cm mass in abdomen with raised values of CA-125, hCG, AFP (alpha-feto protein) and LDH (lactate dehydrogenase). She underwent laparotomy followed by unilateral salpingoopherectomy and infracolic omentectomy. Histopathology report revealed malignant mixed germ cell tumor comprising predominantly of EST with elements of embryonal carcinoma and non-gestational choriocarcinoma. Following surgery, she was started on adjuvant chemotherapy (Bleomycin, Etoposide and Cisplatin regimen). Mixed germ cell tumor (YST/EST, non-gestational choriocarcinoma and embryonal carcinoma) is a very rare tumor. Careful initial surgery with adequate staging biopsies followed by combination chemotherapy can greatly improve the prognosis of these patients

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Author Biography

Aprateem Mukherjee, Department of Obstetrics and Gynecology, Medical College and Hospital, Kolkata, West Bengal, India

Resident, Department of Radiodiagnosis

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Published

2017-05-25

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Case Reports