Partial molar pregnancy associated with a normal appearing foetus: a case report and review of the literature


  • Sujata Singh Department of Obstetrics and Gynecology, S.C.B Medical College and Hospital, Cuttack, Odisha, India
  • Sasmita Swain Department of Obstetrics and Gynecology, S.C.B Medical College and Hospital, Cuttack, Odisha, India
  • Lucy Das Department of Obstetrics and Gynecology, S.C.B Medical College and Hospital, Cuttack, Odisha, India
  • Pravat Chandra Das Community Health Centre, Biridi, Jagatshinghpur, Odisha, India



β hcg, Dizygotic karyotype, Normal foetus, Partial mole, Trisomy 21


Partial molar pregnancy is a rare entity in which there is usually a triploid abnormal foetus associated with a large placenta with cystic changes. The incidence of a normal diploid foetus and a partial molar placenta is extremely rare. Here we report a case of partial molar pregnancy in which a normal appearing foetus with diploid karyotype coexist. In this case a 24yr old primigravida at 20 week 3days gestation presented with 3-4 episodes of vaginal bleeding and generalised swelling of body since one month. On evaluation she was found to have moderate anaemia, proteinuria, raised serum β hcg and USG showed a single live foetus with thickened cystic placenta covering the internal os. After counselling patient was put up for hysterotomy. The product of conception and placenta were sent for histopathology and karyotyping which confirmed partial hydatidiform mole with trisomy 21 foetus. Patient had uneventful post op period and was followed up with serial β hcg measurement which fell to undetectable levels within two months.



Hsieh CC, Hsieh TT, Kuo DM, Lo LM, Hung TH. Delivery of a severely anaemic foetus after partial molar pregnancy: clinical and ultrasonographic findings. Hum Reprod. 1999;14:1122-6.

Suzuki M, Matsunobu A, Vakita K, Osanai K. Hydatidiform mole with surviving co-existent fetus. Ombt Gynecol. 1980;56:384-8.

Vaisbuch E, Ben-Arie A, Dgani R, Perlman S, Sokolovsky N, Hagay Z. Twin pregnancy consisting of a complete hydatidiform mole and co-existent fetus: report of two cases and review of literature. Gynecol Oncol. 2005;98:19-23.

Ohama K, Ueda K, Okamoto E, et al. Cytogenetic and clinicopathological studies of partial moles. Obstet Gynecol. 1986;68:259-66.

Guven ES, Ozturk N, Deveci S, Hizli D, Kandemir O, Dilbaz S. Partial molar pregnancy with coexisting fetus with diploid karyotype. J Matern Fetal Neonatal Med. 2007;20(2):175-181.

Sarno AP, Moorman AJ, Kalousek DK. Partial molar pregency with fetal survival: an unusual example of confined placental mosaicism. Obstet Gynecol. 1993;82:716-9.

Jones WB, Lauersen NH. Hydatidiform mole with coexistent fetus. Am J Obstet Gynecol. 1975;122:267-72.

Deaton JL, Hoffman JS, Saal H, et al. Molar pregnancy coexisting with a normal fetus: a case. Gynecol Oncol. 1989;32:394-7.

Crooiji MJ, Harten VD, Puyenbroek JJ. A partial hydatidi-form mole dispersed throughout the placenta, coexisting with a normal living fetus: case report. Br J Obstet Gynaecol. 1985;92:104-6.

Teng NNH, Ballon SC. Partial hydatidiform mole with diploid karyotype: report of three cases. Am J Obstet Gynecol. 1984;150:961-4.

Szulman, Surti. The syndrome of hydatiform mole (1) cytogenetic and morphological correlations. Am J Obstet Gynaecol. 1978;68:259-66.

Parveen Z, Bashir R, Jadoon T, Qayum L. Partial hydatidiform mole along with term gestation and alive baby. J Ayub Med Coll Abbottabad 2004;16(4):84-5.

Pool R, Lebethe SJ, Lancaster EJ, Partial hydatidiform mole with a coexistent live full term fetus: a case report. S Afr Med J. 1989;75(4):186-7.

Dhingra KK, Gupta P`, Saroha V, Akhila L, Khurana N. Partial hydatidiform mole with a full term infant. Indian J Pathol Microbiol. 2009;52(4):590-1.






Case Reports