DOI: http://dx.doi.org/10.18203/2320-1770.ijrcog20171979

Foetal outcome in pregnancy complicated with viral hepatitis

Harshada S. Thakur, Niranjan Maydeo, Madhuri Kamble

Abstract


Background: The purpose of this study is to study foetal outcome in pregnancy complicated with viral hepatitis, rate of NICU admission and foetal death.

Methods: This is a cross sectional observational study undertaken in the Department of Obstetrics and Gynaecology at the tertiary care centre for the study period from October 2015 to October 2016 approved by ethical committee.

Results: There were 6555 deliveries in study period of October 2015-2016 in which 54 patients were diagnosed with viral hepatitis in pregnancy. Out of 54 patients of viral hepatitis, 30 cases (55.55%) of Hepatitis E virus, 22 cases (40.74%) of Hepatitis B virus, 2 cases (3.7%) of Hepatitis C virus. No case was found for Hepatitis A virus infection. Higher incidence of NICU admission (56.66%), preterm delivery (36.66%) and intra uterine death (23.33%) was observed with Hepatitis E infection.

Conclusions: Foetal outcome was poor in Hepatitis E virus followed by Hepatitis B virus. Acute viral hepatitis is more common cause of hepatitis in pregnancy. Hepatitis E virus was the most common cause of acute infection with adverse fetal outcome. Fetal loss including intra uterine death and preterm neonate was statistically significant with Hepatitis E viral infection. Health education, early diagnosis and multidisciplinary approach is the key to reduce foetal morbidity and mortality. As HBV infection in hepatitis in pregnancy is second most common cause of viral hepatitis, complete immunization against HBV in reproductive age group before first pregnancy is recommended.


Keywords


Hepatitis, Hepatitis E virus, Intrauterine death

Full Text:

PDF

References


Cunningham G, Leveno KJ, Bloom SL. Hepatic, gallbladder, and pancreatic disorders. Williams Obstetrics. 23rd ed, New York, Mac Graw Hill; 2010: 1063.

Shukla S, Mehta G, Jais M, Singh A. A Prospective Study on Acute Viral Hepatitis in Pregnancy; Seroprevalence, and Fetomaternal Outcome of 100 cases. J Biosci Tech. 2011;2 (3):279-86.

Smedile A, Carcil, Verme G. Influence of delta infection on severity of hepatitis B. Lancet. 1982;2:945-7.

Acute Viral Hepatitis. Harrison's Principles of Internal Medicine. 17th Edition. New York, McGraw Hill: Chapter 298.

Lal S, Makharia GK. Liver disorders, Ian Donald. 7th edition; 226-31.

Sahai S, Mishra V, Ganga D, Jatav OP. Viral Hepatitis in Pregnancy -A study of its Effect on Maternal and Foetal Outcome. J Assoc Physic India. 2015;23:28-33.

Wani S, Kadri SM, Bhat S. Prevalence of acute viral hepatitis in women presenting with jaundice with fetomaternal outcome. GJMEDPH. 2013;2(6):1-5.

Mishra S, Jha RK, Thakur R, Tiwari S. Study of maternal and prenatal outcome in pregnant women with acute hepatitis E viral infection. Int J Reprod Contracept Obstet Gynecol. 2016;5(7):2300-3.

Nadar S, Shah MA, Jamil S, Habib H. Maternal and Foetal Outcome in Pregnant Ladies having Acute Hepatitis E. Gomal J Med Sci. 2015;13(1):37-40.

Jethwa DK, Chauhan DV, Badrakiya GL, Badrakiya SG. Hepatitis E virus in pregnancy with fetomaternal outcome-A prospective study. IOSR J Dent Med Sci. 2015;14(8):25-8.

Khuroo MS, Kamili S. Aetiology, clinical course and outcome of sporadic acute viral hepatitis in pregnancy. J Viral Hepat. 2003;10:61-9.

Anwar AL Bassam, Laith A, Yasin A. Outcome of viral hepatitis in pregnancy. Iraqui J Gastroenterol. 2007;2(1):48-53.