DOI: http://dx.doi.org/10.18203/2320-1770.ijrcog20172308

Effect of maternal ABO blood type on birth weight and preeclampsia

Fatma Beyazıt, Eren Pek, Aysenur Çakır Güngör, Meryem Gencer, Mesut A. Unsal

Abstract


Background: ABO blood group has been recognized as a risk factor for distinct disease states. The association between ABO blood group and adverse pregnancy outcomes has not been extensively studied, especially in relation to birth weight and preeclampsia (PE). The aim of the present study is to determine whether ABO blood group contributes to the adverse pregnancy outcomes including low birth weight and PE.

Methods: Medical data including ABO phenotypes were collected from hospital electronic database and retrospectively reviewed. Adverse pregnancy outcomes included PE and low birth weight. Birth week was also noted for each subject.

Results: 2177 charts of mothers who had given birth in our hospital were studied. Overall 605 (27.8%) women had type O blood, 1056 (48.5%) had type A blood, 369 (16.9%) had type B blood and 147 (6.8%) had type AB blood. Pregnant women with type B blood group had significantly lower birth weights compared with type O, A and AB. Birth weeks of all groups were found to be similar with no statistically significant difference. A total of 167 mothers were recorded as having PE. No association was observed between PE and ABO blood groups of study participants.

Conclusions: Although maternal ABO phenotype is associated with low birth weight, no association was found between blood type and preeclampsia. We postulate that maternal/fetal immune system genes which are directly associated with ABO blood groups could affect pregnant with a resulting birth weight alterations.


Keywords


ABO blood type, Birth weight, Pregnancy, Preeclampsia

Full Text:

PDF

References


Shavakhi A, Hajalikhani M, Minakari M, Norian A, Riahi R, Azarnia M, et al. The association of non-O blood group and severity of liver fibrosis in patients with chronic hepatitis C infection. J Res Med Sci. 2012;17(5):466-9.

Khalili H, Wolpin BM, Huang ES, Giovannucci EL, Kraft P, Fuchs CS, et al. ABO blood group and risk of colorectal cancer. Cancer Epidemiol Biomarkers Prev. 2011;20(5):1017-20.

Bir SC, Bollam P, Nanda A. Distribution of ABO blood groups in the patients with intracranial aneurysm and association of different risk factors with particular blood type. Asian J Neurosurg. 2015;10(3):153-7.

Wu O, Bayoumi N, Vickers MA, Clark P. ABO(H) blood groups and vascular disease: a systematic review and meta-analysis. J Thromb Haemost. 2008;6(1):62-9.

Franchini M, Mengoli C, Lippi G. Relationship between ABO blood group and pregnancy complications: a systematic literature analysis. Blood Transfus. 2016;14(5):441-8.

Hosoi E. Biological and clinical aspects of ABO blood group system. J Med Invest. 2008;55(3-4):174-82.

Dentali F, Sironi AP, Ageno W, Crestani S, Franchini M. ABO blood group and vascular disease: an update. Semin Thromb Hemost. 2014;40(1):49-59.

Franchini M, Lippi G. The intriguing relationship between the ABO blood group, cardiovascular disease, and cancer. BMC Med. 2015;13:7.

Phaloprakarn C, Tangjitgamol S. Maternal ABO blood group and adverse pregnancy outcomes. J Perinatol. 2013;33(2):107-11.

Seyfizadeh N, Seyfizadeh N, Yousefi B, Borzoueisileh S, Majidinia M, Shanehbandi D, et al. Is there association between ABO blood group and the risk factors of unfavorable outcomes of pregnancy? J Matern Fetal Neonat Med. 2015;28(5):578-82.

Barden A. Pre-eclampsia: contribution of maternal constitutional factors and the consequences for cardiovascular health. Clin Exp Pharmacol Physiol. 2006;33(9):826-30.

Shinwell ES. Neonatal morbidity of very low birth weight infants from multiple pregnancies. Obstet Gynecol Clin North Am. 2005;32(1):29-38.

Khan NS, Ashraf RN, Noor S, Rahman M, Mashhadi SF, Rashid Z, et al. Association of Maternal Periodontitis with Low Birth Weight in Newborns in a Tertiary Care Hospital. J Ayub Med Coll Abbottabad. 2016;28(1):120-5.

Alpoim PN, de Barros PM, Junqueira DR, Freitas LG, das Graças CM, Fernandes AP, et al. Preeclampsia and ABO blood groups: a systematic review and meta-analysis. Mol Biol Rep. 2013;40(3):2253-61.

Mital P, Gupta D, Benwal DK, Gangwal H, Hooja N, Agarwal S, et al. To find any association of maternal blood group as a risk factor for preeclampsia Int J Comm Med Public Health. 2016;3(12):3445-9.

Hiby SE, Apps R, Chazara O, Farrell LE, Magnus P, Trogstad L, et al. Maternal KIR in combination with paternal HLA-C2 regulate human birth weight. J Immunol. 2014;192(11):5069-73.

Clark P, Walker ID, Govan L, Wu O, Greer IA. The GOAL study: a prospective examination of the impact of factor V Leiden and ABO(H) blood groups on haemorrhagic and thrombotic pregnancy outcomes. Br J Haematol. 2008;140(2):236-40.

Avci D, Karagoz H, Ozer O, Esmeray K, Bulut K, Aykas F, et al. Are the blood groups of women with preeclampsia a risk factor for the development of hypertension postpartum? Therap Clin Risk Manag. 2016;12:617-22.

Spinillo A, Capuzzo E, Baltaro F, Piazzi G, Iasci A. Case-control study of maternal blood group and severe pre-eclampsia. J Hum Hypertens. 1995;9(8):623-5.

Hiltunen LM, Laivuori H, Rautanen A, Kaaja R, Kere J, Krusius T, et al. Blood group AB and factor V Leiden as risk factors for pre-eclampsia: a population-based nested case-control study. Thromb Res. 2009;124(2):167-73.

Hentschke MR, Caruso FB, Paula LG, Medeiros AK, Gadonski G, Antonello IC, et al. Is there any relationship between ABO/Rh blood group and patients with pre-eclampsia? Pregnancy Hypertens. 2014;4(2):170-3.