Pregnancy and lactation associated osteoporosis: unrecognized cause of musculoskeletal pain syndrome during the peri-pregnancy period

Anna Kornete, Ingvars Rasa, Maija Mukane


Pregnancy- and lactation-associated osteoporosis (PLO) is a rare disorder, usually occurring in late pregnancy and the early post-partum period. The prevalence, etiology, pathogenesis and therapy remains unclear. Three clinical cases of PLO present patients with multiple severe osteoporotic fractures during the peri-pregnancy period and different treatment strategies.


Fractures, Lactation, Osteoporosis, Pregnancy

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Sanz-Salvador L, Garcia-Perez MA, Tarin JJ, Cano A. Bone metabolic changes during pregnancy: a period of vulnerability to osteoporosis and fracture. Eur J Endocrinol. 2015;172:53-65.

Nakamura Y, Kamimura M, Shota I, Keijiro M, Masatoshi K, Shigeharu U, Hiroyuki K. A case series of pregnancy- and lactation-associated osteoporosis and a review of the literature. Ther Clin Risk Managm. 2015;11:1361-5.

Raffaeta G, Mazzantini M, Menconi A, Bottai A, Falossi F, Celauro I, Guido G. Osteoporosis with vertebral fractures associated with pregnancy: two case reports. Clin Cases Miner Bone Metab. 2014;11:136-8.

Seok HL, Moon-Ki H, Seung WP, Hyoung-Moo P, Jaetaek K, Jihyun A. A Case of Teriparatide on Pregnancy-Induced Osteoporosis. J Bone Metab. 2013;20:111-4.

Iwamoto J, Yoshihiro S, Mitsuyoshi U, Hideo M. Five-year follow-up of a woman with pregnancy and lactation-associated osteoporosis and vertebral fractures. Ther Clin Risk Managm. 2012;8:195-9.